| Gynecologic oncology in pregnancy. | |
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MedLine Citation:
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PMID: 18296060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this review current knowledge on prevalence, diagnosis, treatment and prognosis of gynaecological malignancies during pregnancy is discussed. After a general overview of surgery, chemotherapy and radiotherapy during pregnancy, tumor specific diagnosis and treatment options are described for breast, cervical, ovarian, endometrial and vulvar cancer. In contrast to previous belief, termination of pregnancy because of a concurrent malignancy does not result in an improved prognosis. Information on prognosis of cancer during pregnancy is often contradictory and evidence on the real influence of pregnancy on prognosis is weak. However, there is increasing belief that, the prognosis per stage is similar to that of the non-pregnant patient and that the risk for impaired prognosis is most likely due to suboptimal diagnosis and treatment. With the exception of pelvic surgery, most surgical techniques that are used in non-pregnant patients are also safe for pregnant patients. Radiotherapy proximal of the upper abdomen is frequently possible, while chemotherapy depending on pregnancy trimester and type of chemotherapy can usually be administered without much hazards. Indications for termination of pregnancy include an unwanted pregnancy and locally advanced cervical cancer. This group of patients is however very small, suggesting that mostly fetal life can be saved. |
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Authors:
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Frédéric Amant; Kristel Van Calsteren; Ignace Vergote; Nelleke Ottevanger |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-03-04 |
Journal Detail:
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Title: Critical reviews in oncology/hematology Volume: 67 ISSN: 1040-8428 ISO Abbreviation: Crit. Rev. Oncol. Hematol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-12 Completed Date: 2008-11-14 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8916049 Medline TA: Crit Rev Oncol Hematol Country: Ireland |
Other Details:
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Languages: eng Pagination: 187-95 Citation Subset: IM |
Affiliation:
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Gynecologic Oncology, Leuven Cancer Institute (LKI), Department of Obstetrics and Gynecology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium. Frederic.amant@uz.kuleuven.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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diagnosis,
therapy Combined Modality Therapy Female Genital Neoplasms, Female / diagnosis, therapy Humans Pregnancy Pregnancy Complications, Neoplastic* / diagnosis, therapy Pregnancy Outcome* Prognosis Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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