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Gynecologic Clostridial Toxic Shock in Women of Reproductive Age.
MedLine Citation:
PMID:  21882086     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Clostridial toxic shock, caused by Clostridium sordellii or Clostridium perfringens, is a rare and largely fatal syndrome among reproductive-aged women with genital tract infection, and may occur following various pregnancy outcomes or without pregnancy. Clinicians should be aware of common clinical features of this very rapidly-progressing syndrome including abdominal pain, tachycardia, hypotension, third-space fluid accumulations, hemoconcentration, and marked leukemoid response, often with lack of fever. In this review, we summarize known cases through mid-2011 and information on clinical presentation, diagnosis, treatment, and results of recent investigations regarding pathogenesis, including germination, toxins, and host response that may have important implications for development of preventive or therapeutic interventions.
Authors:
Suzanne Zane; Jeannette Guarner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-2
Journal Detail:
Title:  Current infectious disease reports     Volume:  -     ISSN:  1534-3146     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888983     Medline TA:  Curr Infect Dis Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Reproductive Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K-23, Atlanta, GA, 30341, USA, saz3@cdc.gov.
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