Document Detail

Gynaecologic cancer complicating pregnancy: an overview.
MedLine Citation:
PMID:  19740709     Owner:  NLM     Status:  MEDLINE    
Cancer complicating pregnancy endangers two lives. Any approach should look at both maternal and foetal safety. Maternal prognosis will not improve by terminating the pregnancy. Imaging for staging purposes is possible, and sonar and magnetic resonance imaging are the preferred examinations. Abdominopelvic computed tomography exposes the foetus to the highest doses radiation and should be avoided. Provided a thorough maternal monitoring to ensure a stable uteroplacental blood flow and foetal oxygenation, surgical techniques that are used in non-pregnant patients are also safe for pregnant patients. Radiotherapy of the upper part of the body is possible during pregnancy, but during the third trimester the close distance may put the foetus at risk. Chemotherapy during the second or third trimester can be administered without increasing the incidence of congenital malformations. A systematic analysis, especially on the long-term outcome of the offspring after cancer treatment during pregnancy is still lacking. Here, we present a summary of issues related to the diagnosis and treatment of gynaecological malignancies during pregnancy. Firstly, we describe general diagnostic and cancer-treatment-related problems. In the second part, organ pathology including breast, cervical, ovarian, endometrial and vulvar cancer is discussed.
Fr?d?ric Amant; Lieselot Brepoels; Michael J Halaska; Mina Mhallem Gziri; Kristel Van Calsteren
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-08
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  24     ISSN:  1532-1932     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  61-79     Citation Subset:  IM    
Obstetrics and Gynaecology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium. <>
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Breast Neoplasms / diagnosis*,  therapy*
Chemotherapy, Adjuvant
Endometrial Neoplasms / diagnosis,  therapy
Genital Neoplasms, Female / diagnosis*,  therapy*
Neoplasm Staging
Ovarian Neoplasms / diagnosis,  therapy
Pregnancy Complications, Neoplastic / diagnosis*,  therapy*
Radiotherapy, Adjuvant
Treatment Outcome
Uterine Cervical Neoplasms / diagnosis,  therapy
Vulvar Neoplasms / diagnosis,  therapy

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