Document Detail


Gutron treatment of patients suffering from essential orthostatic hypotony. Part Two--Autonomic system investigation.
MedLine Citation:
PMID:  7690385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurovegative control of circulatory system in essential orthostatic hypotony (EOH) is not well recognized. Therefore, in group of 9 patients (pts) with EOH treated with midodrine (Gutron, Gu) 5 mg i.v. we performed a study of sympathovagal balance, based on heart rate variability (HRV) analysis. From computer-assisted tachograms we calculated standard deviation of 512 sinus cycles length (SD-SCL) and from power spectral analysis by fast Fourier transformation we derived: amplitudes of high frequency (HF, 0.15-0.35 Hz) and low frequency (LF, 0.05-0.15 Hz) spectra, percentage of power of HF and LF spectra and their ratio, named vegetative control coefficient (VCC, %LF:%HF). Results were compared to that received from control group (11 volunteers). We found that EOH-pts presented lower amplitude of HF, especially after Gu, a lack of increment of %LF irrespective to treatment and higher VCC, which normalized to control value after Gu. We stated that: 1) both branches of autonomic system are disturbed in EOH-patients; 2) Gutron shifts sympatho-vagal balance from initial resting sympathicotomy into parasympathetic predominance.
Authors:
T Petelez; M Sosnowski; I Axenti
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  12     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-08     Completed Date:  1993-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  138-44     Citation Subset:  IM; S    
Affiliation:
III Clinic of Cardiology, Silesian Academy of Medicine, Katowice, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System / drug effects,  physiology*
Electrocardiography / methods*
Female
Fourier Analysis
Heart Rate / drug effects*,  physiology
Humans
Hypotension, Orthostatic / drug therapy*,  physiopathology
Male
Midodrine / therapeutic use*
Signal Processing, Computer-Assisted*
Chemical
Reg. No./Substance:
42794-76-3/Midodrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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