Document Detail

Gut-trophic feed additives and their effects upon the gut structure and intestinal metabolism. State of the art in the pig, and perspectives towards humans.
MedLine Citation:
PMID:  16372249     Owner:  NLM     Status:  MEDLINE    
The correct functional development of the gastrointestinal tract is of special importance during the neonatal and weaning phases of reared piglets. Nutrition is obviously a critical determinant in the growth of the gut in the young swine. The mucosal epithelium of the small intestine is reputed anatomically and functionally immature in neonatal pigs, a feature that appears to be exacerbated at weaning, when a colonization of the gut occurs by "new" microorganisms entering the alimentary canal with the solid feed. This frequently exposes piglets to diarrhoeic syndromes and other intestinal disturbances. Functional feed additives, also called nutraceuticals, appear as promising alternative substances to the use of chemotherapeutics as growth promoters in the rearing farm, above all considering the near banning of them by the European Parliament in the view of reducing antibiotic resistance phenomena in human therapies. Several feed additives are available that may play a role in the pig nutritional plan because of their trophic and cyto-protective effects on the gastrointestinal apparatus. Paying special attention to the quantitative consequences (histometry) upon the gut of the examined dietary supplements, this review, even if not fully exhaustive, will focus on the function (and possibly the mechanism/s of action) of certain gut-trophic nutrient substrates. This in turn will sustain the potential use of these substances in human therapy, especially the one directed at resolving intestinal diseases, both in adult and infant ages. In nutritional studies as well as in other biomedical research fields, the swine is an excellent animal model.
C Domeneghini; A Di Giancamillo; S Arrighi; G Bosi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Histology and histopathology     Volume:  21     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2005-12-22     Completed Date:  2006-04-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  273-83     Citation Subset:  IM    
Department of Veterinary Sciences and Technologies for Food Safety, University of Milan, Milan, Italy.
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MeSH Terms
Animal Feed*
Animal Nutritional Physiological Phenomena
Arginine / metabolism
Cell Proliferation
Diarrhea / microbiology,  veterinary
Dietary Supplements*
Epithelial Cells / cytology
Gastrointestinal Tract / cytology*,  physiology
Glutamic Acid / pharmacology
Glutamine / pharmacology
Intestine, Small / cytology*,  metabolism*,  microbiology
Nucleotides / pharmacology
Probiotics / pharmacology
Reg. No./Substance:
0/Nucleotides; 56-85-9/Glutamine; 56-86-0/Glutamic Acid; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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