Document Detail


Gut response. Therapy with ingested immunomodulatory proteins.
MedLine Citation:
PMID:  9341578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recent negative results of the 2-year phase III trial of enteral myelin (Myloral), a preparation of bovine myelin given orally in multiple sclerosis (MS), warn that the efficacy of oral tolerization (ie, inducing hyporesponsiveness to a specific autoantigen) and the attractiveness of oral desensitization in animal models of MS may not translate into clinical practice. However, such failure should not deter further examination of the mouth, an immunologically interesting and patient-friendly route for immunomodulatory proteins.
Authors:
S A Brod
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of neurology     Volume:  54     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1300-2     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, University of Texas Health Science Center at Houston, USA.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / administration & dosage*,  therapeutic use
Administration, Oral
Animals
Cattle
Clinical Trials as Topic
Humans
Immunotherapy*
Multiple Sclerosis / therapy*
Myelin Sheath / chemistry*
Nerve Tissue Proteins / administration & dosage*,  therapeutic use
Treatment Failure
Grant Support
ID/Acronym/Agency:
R01 NS35619/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Nerve Tissue Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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