Document Detail

Gut protein uptake and mechanisms of meal-induced cortisol release.
MedLine Citation:
PMID:  15585568     Owner:  NLM     Status:  MEDLINE    
The enhanced cortisol release after protein-rich meals might represent a neuroendocrine response to food allergens. We tested whether the antigenicity of proteins contributes to this effect. Twelve healthy men nasogastrically received casein, its less allergenic hydrolysate, and placebo. Contrary to expectations, secretion of cortisol (area under the curve, 742.70 +/- 73.48 vs. 542.95 +/- 70.31 micromol/liter.min, P < 0.03) and ACTH (2020.21 +/- 251.10 vs. 1649.82 +/- 241.23 micromol/liter.min, P < 0.05) was stronger on casein-hydrolysate than casein. Systemic immune activity remained unaffected as indicated by unchanged IL-6 plasma concentrations. This finding indicates that the grade of hydrolysis of a protein and the presence of particular amino acids, rather than its antigenicity, are crucial for the pituitary-adrenal response to nutrients. To further examine whether this response is triggered at the gastrointestinal mucosa or after the substance has reached the circulation, in a supplementary experiment, amino acids were given either nasogastrically or iv to healthy men (n = 4). Only the nasogastric infusion of amino acids induced a significant rise in cortisol concentrations. Serum concentrations of tryptophan, which is known to directly excite the hypothalamo-pituitary-adrenal axis, were comparable for both conditions. We conclude that the meal-related hypothalamo-pituitary-adrenal axis response to amino acids results from a signal that rather acts at the gastrointestinal mucosa than directly via the circulating blood.
Christian Benedict; Manfred Hallschmid; Jürgen Scheibner; Daniel Niemeyer; Bernd Schultes; Volker Merl; Horst L Fehm; Jan Born; Werner Kern
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Publication Detail:
Type:  Journal Article     Date:  2004-12-07
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-10     Completed Date:  2005-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1692-6     Citation Subset:  AIM; IM    
Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, Haus 23a, 23538 Lübeck, Germany.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Caseins / pharmacokinetics
Dietary Proteins / pharmacokinetics*
Eating / physiology*
Food Hypersensitivity / physiopathology
Hydrocortisone / blood*
Interleukin-6 / blood
Intestinal Absorption / physiology*
Intestinal Mucosa / physiology
Intubation, Gastrointestinal
Reg. No./Substance:
0/Caseins; 0/Dietary Proteins; 0/Interleukin-6; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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