| Gut permeability and food allergies. | |
| | |
MedLine Citation:
|
PMID: 21070397 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Intestinal permeability is a critical feature of the gastrointestinal epithelium as it must allow an efficient passage of nutrients and restrict the entry of larger molecules, such as protein antigen, in order to facilitate appropriate immune responses towards food antigens. The proper regulation of the epithelial barrier relies on multiple, intricate physiological and immunologic mechanisms, in terms of which recent progresses regarding the cellular and molecular components have been unravelled. In genetically predisposed individuals, breakdown of oral tolerance can occur, leading to the inadequate production of allergen-specific IgE and the recruitment of mast cells in the gastrointestinal mucosa. Under such conditions, the intestinal permeability towards allergen is altered via different mechanisms, with IgE-CD23-mediated transport across the mucosa playing an important amplification role. Additionally, during the effector phase of the allergic reaction, when mast cells degranulate, a series of inflammatory mediators, such as proteases and cytokines, are released and further affects intestinal permeability. This leads to an increase in the passage of allergens and hence contributes to perpetuate the inflammatory reaction. In this review, we describe the importance of properly balanced intestinal permeability in oral tolerance induction and address the processes involved in damaging the intestinal barrier in the sensitized epithelium and during allergic reactions. We conclude by speculating on the effect of increased intestinal permeability on the onset of sensitization towards dietary antigens. |
| | |
Authors:
|
C Perrier; B Corthésy |
Related Documents
:
|
18381687 - Role of phospholipase a2 and tyrosine kinase in clostridium difficile toxin a-induced d... 11734857 - Extensive surface diversity of a commensal microorganism by multiple dna inversions. 11161457 - Influence of glutamine on cytokine production by human gut in vitro. 20085657 - Lactobacillus acidophilus induces a slow but more sustained chemokine and cytokine resp... 17485377 - Dendritic cells in autoimmune diseases and neuroinflammatory disorders. 19401397 - Intact extracellular matrix and the maintenance of immune tolerance: high molecular wei... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-11 |
Journal Detail:
|
Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 41 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
|
Languages: eng Pagination: 20-8 Citation Subset: IM |
Copyright Information:
|
© 2010 Blackwell Publishing Ltd. |
Affiliation:
|
Division of Gastroenterology, University Hospital, Catholic University Leuven, Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expr...
Next Document: Association of thromboxane A2 receptor (TBXA2R) gene polymorphism in patients with aspirin-intoleran...