Document Detail

Gut mucosal perfusion in infants undergoing cardiopulmonary bypass: effect of preoperative captopril.
MedLine Citation:
PMID:  9301382     Owner:  NLM     Status:  MEDLINE    
We have studied gut mucosal perfusion in 24 infants, aged 0.7-45 weeks, requiring cardiopulmonary bypass (CPB). Group 2 patients (n = 12) had received the angiotensin converting enzyme inhibitor captopril 0.8-0.9 mg kg-1 orally, 45 min before induction of anaesthesia. Group 1 infants were of similar age and size and required a similar duration of CPB, but did not receive any preoperative medication. An orogastric tonometer allowed intermittent calculations of gastric intramucosal pH (pHi), and rectal mucosal perfusion ("flux") was monitored using laser Doppler flowmetry. Measurements of arterial base deficit and lactate and pyruvate concentrations were made intermittently. We found no significant difference in femoral arterial pressure between the groups at any time before, during or after surgery. Similarly, we found no significant differences in our measures of regional or global tissue perfusion between the groups at any time before, during or after surgery. We conclude that preoperative administration of captopril produced no beneficial effect on gut mucosal perfusion in infants undergoing hypothermic, non-pulsatile CPB.
P D Booker; A J Davis; R Franks
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  79     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-03     Completed Date:  1997-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Royal Liverpool Children's NHS Trust.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Captopril / pharmacology*
Cardiopulmonary Bypass*
Gastric Mucosa / blood supply*
Hydrogen-Ion Concentration / drug effects
Intestinal Mucosa / blood supply*
Intraoperative Period
Laser-Doppler Flowmetry
Preanesthetic Medication
Prospective Studies
Rectum / blood supply
Regional Blood Flow / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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