| Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? | |
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MedLine Citation:
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PMID: 21419479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current evidence supports a role for gut colonization in promoting and maintaining a balanced immune response in early life. An altered or less diverse gut microbiota composition has been associated with atopic diseases, obesity, or both. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. However, there has been no fully adequate longitudinal study of the relation between the neonatal gut microbiota and the development of allergic diseases (eg, atopic asthma) and obesity. The emergence of promising experimental studies has led to several clinical trials of probiotics (live bacteria given orally that allow for intestinal colonization) in human subjects. Probiotic trials thus far have failed to show a consistent preventive or therapeutic effect on asthma or obesity. Previous trials of probiotics have been limited by small sample size, short duration of follow-up, or lack of state-of-the art analyses of the gut microbiota. Finally, there is emerging evidence that the vitamin D pathway might be important in gut homeostasis and in signaling between the microbiota and the host. Given the complexity of the gut micriobiota, additional research is needed before we can confidently establish whether its manipulation in early life can prevent or treat asthma, obesity, or both. |
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Authors:
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Ngoc P Ly; Augusto Litonjua; Diane R Gold; Juan C Celedón |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2011-03-21 |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 127 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-07-20 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1087-94; quiz 1095-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA. lyn@peds.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
/
immunology,
microbiology,
physiopathology,
therapy* Child Child, Preschool Clinical Trials as Topic Female Gastrointestinal Tract / immunology, microbiology* Humans Hypersensitivity, Immediate / immunology, microbiology, physiopathology, therapy* Infant Metagenome Obesity / microbiology, therapy* Pregnancy Probiotics / therapeutic use* Treatment Outcome Vitamin D / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI035786-17/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
| Comments/Corrections | |
Comment In:
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J Allergy Clin Immunol. 2011 May;127(5):1128-30
[PMID:
21411129
]
J Allergy Clin Immunol. 2011 Nov;128(5):1133-4; author reply 1134 [PMID: 21855123 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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