Document Detail


Gut microbiota and gastrointestinal health: current concepts and future directions.
MedLine Citation:
PMID:  23279728     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background  The microbial community of the human gut - the enteric microbiota - plays a critical role in functions that sustain health and is a positive asset in host defenses. In recent years, our understanding of this so-called human 'super organism' has advanced, following characterization of fecal metagenomes which identified three core bacterial enterotypes, and based on basic and clinical research into the impact and consequences of microbiota biodiversity and change on gastrointestinal disorders and diseases. Purpose  This article considers current knowledge and future perspectives on the make-up and function of human gut microbiota, with a particular focus on altered microbiota and gastrointestinal disorders, nutritional influences on the gut microbiota, and the consequences for gastrointestinal health, as well as improved understanding of gut-microbiota-brain communication.
Authors:
Q Aziz; J Doré; A Emmanuel; F Guarner; E M M Quigley
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  25     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  4-15     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Affiliation:
Centre for Digestive Diseases, Blizard Institute of Cell & Molecular Science, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK Unité d'Ecologie et Physiologie du Système Digestif, Institut National de la Recherche Agronomique, Jouy en Josas, France GI Physiology Unit, University College, London, UK Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain Department of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
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