Document Detail


Gut microbiome composition is linked to whole grain-induced immunological improvements.
MedLine Citation:
PMID:  23038174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on fecal microbial ecology and blood markers of inflammation, glucose and lipid metabolism. All treatments increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples. The inclusion of WGB enriched the genera Roseburia, Bifidobacterium and Dialister, and the species Eubacterium rectale, Roseburia faecis and Roseburia intestinalis. Whole grains, and especially the BR+WGB treatment, reduced plasma interleukin-6 (IL-6) and peak postprandial glucose. Shifts in the abundance of Eubacterium rectale were associated with changes in the glucose and insulin postprandial response. Interestingly, subjects with greater improvements in IL-6 levels harbored significantly higher proportions of Dialister and lower abundance of Coriobacteriaceae. In conclusion, this study revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.
Authors:
Inés Martínez; James M Lattimer; Kelcie L Hubach; Jennifer A Case; Junyi Yang; Casey G Weber; Julie A Louk; Devin J Rose; Gayaneh Kyureghian; Daniel A Peterson; Mark D Haub; Jens Walter
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-04
Journal Detail:
Title:  The ISME journal     Volume:  7     ISSN:  1751-7370     ISO Abbreviation:  ISME J     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-11-14     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101301086     Medline TA:  ISME J     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Bacteroidetes / growth & development
Bifidobacterium / growth & development
Biodiversity
Biological Markers / blood
Blood Glucose / analysis
Cereals*
Cross-Over Studies
Diet*
Eubacterium / growth & development
Feces / microbiology
Female
Gastrointestinal Tract / immunology,  metabolism,  microbiology*
Hordeum
Humans
Inflammation / blood
Insulin / blood
Interleukin-6 / blood
Male
Metagenome*
Oryza sativa
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Insulin; 0/Interleukin-6
Comments/Corrections
Comment In:
Gut Microbes. 2013 Jul-Aug;4(4):340-6   [PMID:  23645316 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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