| Gut microbiome composition is linked to whole grain-induced immunological improvements. | |
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MedLine Citation:
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PMID: 23038174 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on fecal microbial ecology and blood markers of inflammation, glucose and lipid metabolism. All treatments increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples. The inclusion of WGB enriched the genera Roseburia, Bifidobacterium and Dialister, and the species Eubacterium rectale, Roseburia faecis and Roseburia intestinalis. Whole grains, and especially the BR+WGB treatment, reduced plasma interleukin-6 (IL-6) and peak postprandial glucose. Shifts in the abundance of Eubacterium rectale were associated with changes in the glucose and insulin postprandial response. Interestingly, subjects with greater improvements in IL-6 levels harbored significantly higher proportions of Dialister and lower abundance of Coriobacteriaceae. In conclusion, this study revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.The ISME Journal advance online publication, 4 October 2012; doi:10.1038/ismej.2012.104. |
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Authors:
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Inés Martínez; James M Lattimer; Kelcie L Hubach; Jennifer A Case; Junyi Yang; Casey G Weber; Julie A Louk; Devin J Rose; Gayaneh Kyureghian; Daniel A Peterson; Mark D Haub; Jens Walter |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-04 |
Journal Detail:
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Title: The ISME journal Volume: - ISSN: 1751-7370 ISO Abbreviation: ISME J Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101301086 Medline TA: ISME J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Food Science and Technology, University of Nebraska, Lincoln, NE, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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