Document Detail


Gut hormones as potential new targets for appetite regulation and the treatment of obesity.
MedLine Citation:
PMID:  18197723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food intake and bodyweight are tightly regulated by the brainstem, hypothalamus and reward circuits. These centres integrate diverse cognitive inputs with humoral and neuronal signals of nutritional status. Our knowledge of the role of gut hormones in this complex homeostatic system has expanded enormously in recent years. This review discusses both the role of gut hormones in appetite regulation, and the current state of development of gut hormone-based obesity therapies, with a particular focus on pancreatic polypeptide, peptide YY, amylin, glucagon-like peptide-1, oxyntomodulin, cholecystokinin and ghrelin. Several gut hormone-based treatments for obesity are under investigation in phase II and III clinical trials, and many more are in the pipeline.
Authors:
Benjamin C T Field; Alison M Wren; Dunstan Cooke; Stephen R Bloom
Related Documents :
16979293 - Neuropeptide y mediates ghrelin-induced feeding in the goldfish, carassius auratus.
12376313 - Expression of fas within hypothalamic neurons: a model for decreased food intake after ...
1951983 - Seasonal variation in the proliferation fraction of australian common nevi.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Drugs     Volume:  68     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  147-63     Citation Subset:  IM    
Affiliation:
Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD26 / antagonists & inhibitors
Appetite Regulation / drug effects*
Clinical Trials as Topic
Gastrointestinal Hormones / therapeutic use*
Humans
Obesity / drug therapy*
Receptors, Ghrelin / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
//Medical Research Council
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Receptors, Ghrelin; EC 3.4.14.5/Antigens, CD26; EC 3.4.14.5/DPP4 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  New therapeutic options for chemotherapy-resistant metastatic breast cancer: the epothilones.
Next Document:  Treatment options for multidrug-resistant Acinetobacter species.