Document Detail

Gut hormones as potential new targets for appetite regulation and the treatment of obesity.
MedLine Citation:
PMID:  18197723     Owner:  NLM     Status:  MEDLINE    
Food intake and bodyweight are tightly regulated by the brainstem, hypothalamus and reward circuits. These centres integrate diverse cognitive inputs with humoral and neuronal signals of nutritional status. Our knowledge of the role of gut hormones in this complex homeostatic system has expanded enormously in recent years. This review discusses both the role of gut hormones in appetite regulation, and the current state of development of gut hormone-based obesity therapies, with a particular focus on pancreatic polypeptide, peptide YY, amylin, glucagon-like peptide-1, oxyntomodulin, cholecystokinin and ghrelin. Several gut hormone-based treatments for obesity are under investigation in phase II and III clinical trials, and many more are in the pipeline.
Benjamin C T Field; Alison M Wren; Dunstan Cooke; Stephen R Bloom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Drugs     Volume:  68     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  147-63     Citation Subset:  IM    
Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK.
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MeSH Terms
Antigens, CD26 / antagonists & inhibitors
Appetite Regulation / drug effects*
Clinical Trials as Topic
Gastrointestinal Hormones / therapeutic use*
Obesity / drug therapy*
Receptors, Ghrelin / antagonists & inhibitors
Grant Support
//Medical Research Council
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Receptors, Ghrelin; EC, CD26; EC protein, human

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