| Gut hormones and appetite control. | |
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MedLine Citation:
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PMID: 18939959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gastrointestinal tract is the largest endocrine organ in the body. It secretes more than 20 different peptide hormones, which serve both a local regulatory function and provide a means by which the gut can regulate appetite and satiety. As the worldwide prevalence of obesity reaches epidemic proportions, the importance of delineating the mechanisms which regulate food intake becomes even more urgent. There is now a substantial body of work in both rodent and human models demonstrating the effects of these peptides on appetite and work is underway to therapeutically manipulate the gut-brain axis for the treatment of obesity. In addition, it may also be possible to use our understanding of the entero-endocrine system to treat calorie-deficient states. |
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Authors:
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S Hameed; W S Dhillo; S R Bloom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-10-17 |
Journal Detail:
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Title: Oral diseases Volume: 15 ISSN: 1601-0825 ISO Abbreviation: Oral Dis Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 18-26 Citation Subset: D |
Affiliation:
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Department of Investigative Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation / physiology* Cholecystokinin / physiology Eating / physiology Gastrointestinal Hormones / physiology* Ghrelin / physiology Glucagon-Like Peptide 1 / physiology Humans Models, Animal Obesity / therapy Oxyntomodulin / physiology Pancreatic Polypeptide / physiology Peptide YY / physiology Satiety Response / physiology |
| Grant Support | |
ID/Acronym/Agency:
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//Department of Health; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones; 0/Ghrelin; 0/Oxyntomodulin; 106388-42-5/Peptide YY; 59763-91-6/Pancreatic Polypeptide; 89750-14-1/Glucagon-Like Peptide 1; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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