| Gut hormone PYY(3-36) physiologically inhibits food intake. | |
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MedLine Citation:
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PMID: 12167864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Food intake is regulated by the hypothalamus, including the melanocortin and neuropeptide Y (NPY) systems in the arcuate nucleus. The NPY Y2 receptor (Y2R), a putative inhibitory presynaptic receptor, is highly expressed on NPY neurons in the arcuate nucleus, which is accessible to peripheral hormones. Peptide YY(3-36) (PYY(3-36)), a Y2R agonist, is released from the gastrointestinal tract postprandially in proportion to the calorie content of a meal. Here we show that peripheral injection of PYY(3-36) in rats inhibits food intake and reduces weight gain. PYY(3-36) also inhibits food intake in mice but not in Y2r-null mice, which suggests that the anorectic effect requires the Y2R. Peripheral administration of PYY(3-36) increases c-Fos immunoreactivity in the arcuate nucleus and decreases hypothalamic Npy messenger RNA. Intra-arcuate injection of PYY(3-36) inhibits food intake. PYY(3-36) also inhibits electrical activity of NPY nerve terminals, thus activating adjacent pro-opiomelanocortin (POMC) neurons. In humans, infusion of normal postprandial concentrations of PYY(3-36) significantly decreases appetite and reduces food intake by 33% over 24 h. Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway. |
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Authors:
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Rachel L Batterham; Michael A Cowley; Caroline J Small; Herbert Herzog; Mark A Cohen; Catherine L Dakin; Alison M Wren; Audrey E Brynes; Malcolm J Low; Mohammad A Ghatei; Roger D Cone; Stephen R Bloom |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nature Volume: 418 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-08 Completed Date: 2002-09-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 650-4 Citation Subset: IM |
Affiliation:
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Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Appetite / drug effects*, physiology Arcuate Nucleus / cytology, drug effects, physiology Body Weight / drug effects Electrophysiology Energy Intake / drug effects Feeding Behavior / drug effects*, physiology Gene Deletion Humans Injections, Intraperitoneal Injections, Intraventricular Leptin / blood Male Mice Mice, Inbred C57BL Mice, Knockout Neurons / drug effects, physiology Peptide YY / administration & dosage, pharmacology* Pro-Opiomelanocortin / metabolism Proto-Oncogene Proteins c-fos / metabolism Rats Rats, Wistar Receptors, Neuropeptide Y / genetics, metabolism Signal Transduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Proto-Oncogene Proteins c-fos; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y2 receptor; 106388-42-5/Peptide YY; 123583-37-9/peptide YY (3-36); 66796-54-1/Pro-Opiomelanocortin |
| Comments/Corrections | |
Comment In:
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Nature. 2004 Jul 8;430(6996):1 p following 165; discussion 2 p following 165
[PMID:
15243972
]
Nature. 2002 Aug 8;418(6898):595-7 [PMID: 12167841 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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