Document Detail

Gut flora and bacterial translocation in chronic liver disease.
MedLine Citation:
PMID:  16570339     Owner:  NLM     Status:  MEDLINE    
Increasing evidence suggests that derangement of gut flora is of substantial clinical relevance to patients with cirrhosis. Intestinal bacterial overgrowth and increased bacterial translocation of gut flora from the intestinal lumen, in particular, predispose to an increased potential for bacterial infection in this group. Recent studies suggest that, in addition to their role in the pathogenesis of overt infective episodes and the clinical consequences of sepsis, gut flora contributes to the pro-inflammatory state of cirrhosis even in the absence of overt infection. Furthermore, manipulation of gut flora to augment the intestinal content of lactic acid-type bacteria at the expense of other gut flora species with more pathogenic potential may favourably influence liver function in cirrhotic patients. Here we review current concepts of the various inter-relationships between gut flora, bacterial translocation, bacterial infection, pro-inflammatory cytokine production and liver function in this group.
John Almeida; Sumedha Galhenage; Jennifer Yu; Jelica Kurtovic; Stephen M Riordan
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  12     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-29     Completed Date:  2006-08-22     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1493-502     Citation Subset:  IM    
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MeSH Terms
Antibiotic Prophylaxis
Bacterial Infections / physiopathology,  prevention & control
Bacterial Translocation*
Chronic Disease
Gastrointestinal Tract / microbiology*,  physiology
Liver / microbiology,  physiopathology
Liver Cirrhosis / microbiology,  physiopathology
Liver Diseases / microbiology*,  physiopathology*
Peritonitis / physiopathology,  prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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