| Gut failure in the ICU. | |
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MedLine Citation:
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PMID: 21989698 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The role of dysfunction of the gastrointestinal tract in the pathogenesis of multiple organ failure (MOF) complicating the course of critically ill patients has been suspected for more than 40 years. However, several hypotheses have been proposed and sometimes refuted to establish a link. This review summarizes the current knowledge on gastrointestinal physiology and recapitulates existing evidence on the link between gastrointestinal dysfunction and MOF. The gastrointestinal tract has various functions apart from digestion. It produces hormones with local and systemic effects, plays a major role in immunological function, and serves as a barrier against antigens within its lumen. Gastrointestinal dysfunction or gut failure is frequently encountered in critical care patients and is associated with bacterial translocation, which can lead to the development of sepsis, initiation of a cytokine-mediated systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and death. The aim of this manuscript is to define gut failure, to review physiopathological mechanisms and clinical implications, and, finally, to suggest preventive measures. |
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Authors:
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Francesco Puleo; Marianna Arvanitakis; André Van Gossum; Jean-Charles Preiser |
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Publication Detail:
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Type: Journal Article Date: 2011-10-11 |
Journal Detail:
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Title: Seminars in respiratory and critical care medicine Volume: 32 ISSN: 1098-9048 ISO Abbreviation: Semin Respir Crit Care Med Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431858 Medline TA: Semin Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 626-38 Citation Subset: IM |
Copyright Information:
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© Thieme Medical Publishers. |
Affiliation:
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Department of Gastroenterology, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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