Document Detail

Gut barrier dysfunction in food allergy.
MedLine Citation:
PMID:  16292078     Owner:  NLM     Status:  MEDLINE    
Intestinal permeability tests used in the diagnosis of allergic diseases in response to oral food challenge have led to the conclusion that constitutive defects of the intestinal barrier are not the primary cause of allergic diseases. However, perturbation of environmental factors (infection, stress), by increasing intestinal permeability and enhancing danger signals, may favour food allergy in susceptible individuals. The mechanisms of enhanced permeability to specific and bystander antigens have been delineated as well as the molecular events involved in the sequential phases of allergic reactions. Intestinal absorption of food antigens and immune responses are mutually dependent, and luminal (environmental) and serosal (intrinsic) factors synergize to maintain a self-perpetuating cycle in which antigens penetrate the mucosa and induce allergic inflammation.
Martine Heyman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  17     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-06-29     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1279-85     Citation Subset:  IM    
Faculté de Médecine Necker-Enfants Malades, Paris, France.
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MeSH Terms
Antigens / metabolism
Food Hypersensitivity / immunology,  physiopathology*
Infection / physiopathology
Intestinal Absorption / immunology*
Intestinal Mucosa / immunology,  metabolism
Stress, Psychological / physiopathology
Reg. No./Substance:

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