| Gut adaptation and the insulin-like growth factor system: regulation by glutamine and IGF-I administration. | |
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MedLine Citation:
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PMID: 8944702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal adaptation after extensive small bowel resection in rats is augmented by the provision of diets supplemented with the amino acid glutamine (Gln) or by administration of insulin-like growth factor-I (IGF-I). The goal of this study was to investigate potential synergistic effects of Gln and IGF-I on postresection ileal hyperplasia. Rats underwent 80% small bowel resection (SBR) and then were fed low-Gln or L-Gln-enriched diets and subcutaneously given recombinant human IGF-I or vehicle for 7 days. Gln and IGF-I each significantly enhanced adaptive ileal hyperplasia (DNA content) compared with rats receiving vehicle and low-Gln diet. Ileal DNA content was highest when IGF-I was administered together with Gln supplementation. Combined IGF-I plus Gln synergistically increased ileal weight and protein content. This was associated with higher plasma concentrations of IGF-I and Gln than observed when IGF-I or Gln was given individually. Ileal IGF-I mRNA expression rose nearly twofold during gut adaptation after SBR; this response was augmented with IGF-I administration but was unaltered by Gln feeding. In contrast, dietary Gln, but not IGF-I therapy, prevented a decrease in hepatic IGF-I mRNA induced by SBR. We conclude that parenteral IGF-I and enteral Gln have both individual and synergistic effects on ileal adaptation after massive small intestinal resection. These findings support the concept that specific gut-trophic nutrients and growth factors may be combined to enhance intestinal adaptation and possibly reduce the severity of short bowel syndrome after intestinal resection. |
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Authors:
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T R Ziegler; M P Mantell; J C Chow; J L Rombeau; R J Smith |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-01-09 Completed Date: 1997-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G866-75 Citation Subset: IM |
Affiliation:
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Joslin Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Enteral Nutrition Food, Fortified* Glutamine / pharmacology* Humans Hyperplasia Ileum / drug effects, pathology, physiology* Insulin-Like Growth Factor Binding Protein 3 / biosynthesis Insulin-Like Growth Factor Binding Protein 4 / biosynthesis Insulin-Like Growth Factor I / biosynthesis*, metabolism, pharmacology* Intestine, Small / physiology*, surgery Liver / drug effects, physiology Male Muscle, Smooth / drug effects, pathology, physiology RNA, Messenger / biosynthesis Rats Rats, Sprague-Dawley Recombinant Proteins / pharmacology Transcription, Genetic* / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DK-43038/DK/NIDDK NIH HHS; DK-48503/DK/NIDDK NIH HHS; GM-36428/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Protein 3; 0/Insulin-Like Growth Factor Binding Protein 4; 0/RNA, Messenger; 0/Recombinant Proteins; 56-85-9/Glutamine; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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