Document Detail

Gut Microbiota of the Very Low Birth Weight Infant.
MedLine Citation:
PMID:  25310760     Owner:  NLM     Status:  Publisher    
The microbiome, of which the bacterial component alone (microbiota), is estimated to include 10 times more cells than human cells of the body, blooms immediately after birth and evolves in composition and complexity throughout childhood. The gut microbiome has a profound impact on gastrointestinal tract development, maintenance of mucosal surface integrity and contributes to the nutritional status of the host; and thus plays a pivotal role in health and disease. New technologies have enabled the detailed characterization of normal microbial symbionts and dysbiosis - disease associations. This review summarizes the step-wise establishment of the intestinal microbiota, influential environmental factors and how this may be perturbed in preterm very low birth weight infants. The contribution of the microbiota to provision of energy and nutrients for intestinal development and the nutritional status of the host are reviewed. In addition the crucial role of the gut microbiota in maintaining mucosal integrity is explored along with how its breakdown can lead to sepsis, necrotizing enterocolitis and systemic inflammatory response syndrome. Finally the role of enteral feeding type (human milk, formula and nutrient fortification) in mediating these processes is discussed and guidance is provided for nutritional strategies to promote health in these fragile infants.Pediatric Research (2014); doi:10.1038/pr.2014.162.
Sharon Unger; Alain Stintzi; Prakeshkumar Shah; David Mack; Deborah L O'Connor
Publication Detail:
Type:  REVIEW     Date:  2014-10-13
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-13     Completed Date:  -     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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