| Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. | |
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MedLine Citation:
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PMID: 23363771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To investigate the role of the gut microbiome, we studied 317 Malawian twin pairs during the first 3 years of life. During this time, half of the twin pairs remained well nourished, whereas 43% became discordant, and 7% manifested concordance for acute malnutrition. Both children in twin pairs discordant for kwashiorkor were treated with a peanut-based, ready-to-use therapeutic food (RUTF). Time-series metagenomic studies revealed that RUTF produced a transient maturation of metabolic functions in kwashiorkor gut microbiomes that regressed when administration of RUTF was stopped. Previously frozen fecal communities from several discordant pairs were each transplanted into gnotobiotic mice. The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate, and intermediary metabolism that were only transiently ameliorated with RUTF. These findings implicate the gut microbiome as a causal factor in kwashiorkor. |
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Authors:
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Michelle I Smith; Tanya Yatsunenko; Mark J Manary; Indi Trehan; Rajhab Mkakosya; Jiye Cheng; Andrew L Kau; Stephen S Rich; Patrick Concannon; Josyf C Mychaleckyj; Jie Liu; Eric Houpt; Jia V Li; Elaine Holmes; Jeremy Nicholson; Dan Knights; Luke K Ursell; Rob Knight; Jeffrey I Gordon |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study Date: 2013-01-30 |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 339 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-01 Completed Date: 2013-02-06 Revised Date: 2013-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 548-54 Citation Subset: IM |
Affiliation:
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Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Animals Arachis hypogaea Carbohydrate Metabolism Child, Preschool Feces / microbiology Female Gastrointestinal Tract / microbiology* Germ-Free Life Humans Infant Kwashiorkor / diet therapy, epidemiology, microbiology* Longitudinal Studies Malawi / epidemiology Male Metagenome* Mice Mice, Inbred C57BL |
| Grant Support | |
ID/Acronym/Agency:
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DK078669/DK/NIDDK NIH HHS; DK30292/DK/NIDDK NIH HHS; P01 DK078669/DK/NIDDK NIH HHS; R37 DK030292/DK/NIDDK NIH HHS; T32-HD049338/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
| Comments/Corrections | |
Comment In:
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Science. 2013 Feb 1;339(6119):530-2
[PMID:
23363770
]
Cell Host Microbe. 2013 Mar 13;13(3):239-40 [PMID: 23498946 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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