Document Detail


Gut microbiomes of Malawian twin pairs discordant for kwashiorkor.
MedLine Citation:
PMID:  23363771     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To investigate the role of the gut microbiome, we studied 317 Malawian twin pairs during the first 3 years of life. During this time, half of the twin pairs remained well nourished, whereas 43% became discordant, and 7% manifested concordance for acute malnutrition. Both children in twin pairs discordant for kwashiorkor were treated with a peanut-based, ready-to-use therapeutic food (RUTF). Time-series metagenomic studies revealed that RUTF produced a transient maturation of metabolic functions in kwashiorkor gut microbiomes that regressed when administration of RUTF was stopped. Previously frozen fecal communities from several discordant pairs were each transplanted into gnotobiotic mice. The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate, and intermediary metabolism that were only transiently ameliorated with RUTF. These findings implicate the gut microbiome as a causal factor in kwashiorkor.
Authors:
Michelle I Smith; Tanya Yatsunenko; Mark J Manary; Indi Trehan; Rajhab Mkakosya; Jiye Cheng; Andrew L Kau; Stephen S Rich; Patrick Concannon; Josyf C Mychaleckyj; Jie Liu; Eric Houpt; Jia V Li; Elaine Holmes; Jeremy Nicholson; Dan Knights; Luke K Ursell; Rob Knight; Jeffrey I Gordon
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study     Date:  2013-01-30
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  339     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-02-06     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  548-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism
Animals
Arachis hypogaea
Carbohydrate Metabolism
Child, Preschool
Diseases in Twins / microbiology*
Feces / microbiology
Female
Gastrointestinal Tract / microbiology*
Germ-Free Life
Humans
Infant
Kwashiorkor / diet therapy,  epidemiology,  microbiology*
Longitudinal Studies
Malawi / epidemiology
Male
Metagenome*
Mice
Mice, Inbred C57BL
Grant Support
ID/Acronym/Agency:
DK078669/DK/NIDDK NIH HHS; DK30292/DK/NIDDK NIH HHS; F32 DK091044/DK/NIDDK NIH HHS; P01 DK078669/DK/NIDDK NIH HHS; R37 DK030292/DK/NIDDK NIH HHS; T32 GM008759/GM/NIGMS NIH HHS; T32 HD049338/HD/NICHD NIH HHS; T32-HD049338/HD/NICHD NIH HHS; T35 DK074375/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids
Comments/Corrections
Comment In:
Cell Host Microbe. 2013 Mar 13;13(3):239-40   [PMID:  23498946 ]
Science. 2013 Feb 1;339(6119):530-2   [PMID:  23363770 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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