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Gut Bacterial Translocation is associated with Microinflammation in End Stage Renal Disease Patients.
MedLine Citation:
PMID:  22817644     Owner:  NLM     Status:  Publisher    
SUMMARY AT A GLANCE: Wang et al evaluated the bacterial translocation in the intestinal tract in non-dialysed ESRD patients and its contribution to micoinflammation in the patient population. ABSTRACT: Aims:  To investigate whether gut bacteria translocation occurs in end-stage renal disease patients and contributes to microinflammation in end stage renal disease. Methods:  The subjects were divided into two groups: nondialysed end stage renal disease patients (n = 30) and healthy controls (n = 10). Blood samples from all participants were subjected to bacterial 16S ribosomal DNA amplification and DNA pyrosequencing to determine the presence of bacteria, and the alteration of gut microbiomes were examined with the same methods. High-sensitive C-reactive protein and interleukin-6 were detected. Plasma D-lactate was tested for gut permeability. Results:  Bacterial DNAs were detected in the blood of 20% (6/30) of the end stage renal disease patients. All the observed genera in blood (Klebsiella spp, Proteus spp, Escherichia spp, Enterobacter spp, and Pseudomonas spp) were overgrown in the guts of the ESRD patients. Plasma D-lactate, High-sensitive C-reactive protein, and interleukin-6 levels were significantly higher in patients with bacterial DNA than those without. The control group showed the same results as that of patients without bacterial DNA. Conclusion:  Bacterial translocation occurs in end stage renal disease patients and is associated with microinflammation in end stage renal disease. © 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Feiqian Wang; Hongli Jiang; Kehui Shi; Yi Ren; Pan Zhang; Shaoli Cheng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-23
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology.
Medicine School of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Dialysis Center of First Affiliated Hospital of Medicine School, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China; Morphological Experiment Centre, Medicine School of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
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