| Gustation genetics: sweet gustducin! | |
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MedLine Citation:
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PMID: 20660058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two recent studies, the second of which is reported herein, provide evidence that genetic variation in the sweet receptor subunit, TAS1R3, and the second messenger, gustducin (GNAT3), affect the ability of people to correctly sort ascending concentrations of sucrose. These findings raise questions about how variation in the TAS1R3 and GNAT3 gene shape the human sweet tooth and its unwelcome consequences, diabetes and obesity. |
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Authors:
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Danielle R Reed; Robert F Margolskee |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-21 |
Journal Detail:
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Title: Chemical senses Volume: 35 ISSN: 1464-3553 ISO Abbreviation: Chem. Senses Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-12-27 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 8217190 Medline TA: Chem Senses Country: England |
Other Details:
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Languages: eng Pagination: 549-50 Citation Subset: IM |
Affiliation:
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Monell Chemical Senses Center, Philadelphia, PA 19104, USA. reed@monell.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Genetic Variation Humans Receptors, G-Protein-Coupled / genetics, metabolism Sucrose / chemistry*, pharmacology Taste / drug effects* Taste Buds / metabolism Transducin / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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DC00992/DC/NIDCD NIH HHS; DC03055/DC/NIDCD NIH HHS; DC03155/DC/NIDCD NIH HHS; R01 DC003055-12S1/DC/NIDCD NIH HHS; R01 DC003055-13/DC/NIDCD NIH HHS; R01 DC003155-11A1/DC/NIDCD NIH HHS; R01 DC003155-12/DC/NIDCD NIH HHS; R01 DC004698/DC/NIDCD NIH HHS; R03 DC003509/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, G-Protein-Coupled; 0/taste receptors, type 1; 147979-21-3/Gnat3 protein, rat; 57-50-1/Sucrose; EC 3.6.1.-/Transducin |
| Comments/Corrections | |
Comment On:
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Chem Senses. 2010 Sep;35(7):579-92
[PMID:
20660057
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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