Document Detail

Guinea-pig tracheal responsiveness in vitro following general anaesthesia with halothane.
MedLine Citation:
PMID:  8836658     Owner:  NLM     Status:  MEDLINE    
Halothane and isoflurane induce potent bronchodilation during general anaesthesia and have been used successfully during status asthmaticus. The aim of this study was to determine whether airway hyporesponsiveness was prolonged after halothane administration. Sixteen guinea-pigs were submitted for 2 h to either 1.5% halothane in oxygen or 100% oxygen, and were killed 24 h later to elicit isometric tracheal contractions in organ baths with various agonists. Cumulative concentration-response curves to histamine or to KCl and contractions evoked with acetylcholine 1 mM (4.7 +/- 0.8 vs 4.6 +/- 0.5 g) or carbachol 10 microM in calcium-free buffer (4.3 +/- 0.6 vs 4.4 +/- 0.6 g) exhibited no difference between groups. Moreover, when 4% halothane or 4.6% isoflurane were directly bubbled through the organ baths, a significant decrease (13 +/- 1% and 37 +/- 2%) of maximal contractions evoked with acetylcholine and KCI, respectively, was obtained but these relaxant effects did not persist 30 min after cessation of anaesthetic. These results indicate that, even though halothane induces transient airway hyporesponsiveness in vitro, previous halothane anaesthesia in guinea-pigs does not alter subsequent tracheal responsiveness assessed in vitro. Our findings may explain the transient renewal of bronchospasm reported during intermittent periods off halothane in status asthmaticus.
F J Mercier; A Denjean
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  9     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-16     Completed Date:  1996-12-16     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1451-5     Citation Subset:  IM    
Département d' Anaesthésie, Université Paris-Sud, Hôpital A. Béclèrc, Clamart, France.
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MeSH Terms
Anesthesia, General*
Anesthetics, Inhalation / pharmacology*
Guinea Pigs
Halothane / pharmacology*
Isoflurane / pharmacology
Muscle Contraction / drug effects,  physiology
Muscle, Smooth / drug effects,  physiology*
Time Factors
Trachea / drug effects,  physiology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 151-67-7/Halothane; 26675-46-7/Isoflurane

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