Document Detail

Guinea pig has a unique mammalian VIP.
MedLine Citation:
PMID:  4004849     Owner:  NLM     Status:  MEDLINE    
Mammalian vasoactive intestinal peptide (VIP) has been reported to be identical in four species. This report describes the extraction of guinea pig (GP) intestinal VIP, its purification and sequence. Frozen intestines were extracted in five volumes of methanol and the methanol cakes reextracted with acid. VIP in the acid extract was concentrated onto ion-exchange cellulose and was brought to final purity through a series of HPLC steps. GP VIP differs from other mammalian VIP's by four amino acid substitutions: (sequence in text) This is further evidence that the GP gastroenteropancreatic axis has a unique evolutionary separation from other mammals.
B H Du; J Eng; J D Hulmes; M Chang; Y C Pan; R S Yalow
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  128     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-10     Completed Date:  1985-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1093-8     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Guinea Pigs / genetics*
Species Specificity
Vasoactive Intestinal Peptide / genetics,  isolation & purification*
Reg. No./Substance:
37221-79-7/Vasoactive Intestinal Peptide

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