Document Detail


The Guinea Pig Model of Legionnaires' Disease.
MedLine Citation:
PMID:  23150418     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The guinea pig pneumonia model mimics Legionnaires' disease as seen in immunocompromised humans, with high untreated fatality rates and as such lends itself to studies of experimental chemotherapy. Guinea pig infection is also used to assess relative virulence of different Legionella bacterial strains, and has also been used to study host immune defenses. Here I describe the method used to produce Legionella sp. pneumonia in the guinea pig using the intratracheal infection technique. This method uses directly observed intratracheal injection of a bacterial suspension, requiring surgical exposure of the trachea.
Authors:
Paul H Edelstein
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  954     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  521-540     Citation Subset:  -    
Affiliation:
Clinical Microbiology Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, phe@mail.med.upenn.edu.
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