| Guillian-barre syndrome. | |
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MedLine Citation:
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PMID: 22081202 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Guillian-Barre syndrome (GBS) is the most common cause of acute flaccid paralysis. All age groups can be affected, more common in elderly. Campylobacter jejuni, a major cause of bacterial gastroenteritis worldwide has become recognized as a most frequent antecedent pathogen for GBS. A prospective case-controlled study showed, positive C. Jejuni serology was found in an unprecedented high frequency of 57% as compared to 8% in family controls and 3% in control patients with other neurological diseases. In GBS there is molecular mimicry between epitops found in the cell walls of some micro-organisms and gangliosides in schwann cell membrane. Diagnosis is mainly clinical. The mainstay of treatment of GBS is supportive care and prevention of complications. Respiratory failure and autonomic dysfunction are the common causes of death from GBS. Plasma exchange and intravenous immunoglobulin therapy shorten the duration of ventilation and improve prognosis. Overall, prognosis of GBS is good. Eighty percent of patients recover completely within 3-6 months, 4% die, and the remainder suffers residual neurological disability. GBS may be prevented by development of a vaccine against C. Jejuni. Early and specific diagnosis is important to ensure a favourable outcome. |
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Authors:
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R K Talukder; S R Sutradhar; K M Rahman; M J Uddin; H Akhter |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mymensingh medical journal : MMJ Volume: 20 ISSN: 1022-4742 ISO Abbreviation: Mymensingh Med J Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9601799 Medline TA: Mymensingh Med J Country: Bangladesh |
Other Details:
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Languages: eng Pagination: 748-56 Citation Subset: IM |
Affiliation:
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Dr Mohmmad Rezaul Karim Talukder, MD Student (Neurology) Part-2, Mymensingh Medical College, Mymensingh, Bangladesh. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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