Document Detail

Guillain-Barré syndrome in immunocompromised patients: a report of three patients and review of the literature.
MedLine Citation:
PMID:  9236791     Owner:  NLM     Status:  MEDLINE    
Both humoral and cell-mediated autoimmune mechanisms have been implicated in the pathogenesis of Guillain-Barré syndrome (GBS). Therefore, its occurrence in severely immunocompromised patients is not expected. We identified 3 severely immunocompromised patients who developed GBS. Two of the 3 patients had acquired immunodeficiency syndrome with CD4 counts of 5 and 4 cells/mm3, respectively. One post-cardiac transplant patient was taking azathioprine and cyclosporine at the time of onset of GBS. In all 3 patients, immunocompromise was induced by infectious or chemotherapeutic agents which preferentially suppress T-lymphocyte responses. All 3 had severe lymphocytopenia and incomplete recovery. We conclude that GBS can occur in patients with severe t-cell suppression. Although no conclusion regarding prognosis can be drawn from our small group of patients, their incomplete recovery is consistent with the idea that T-cells are important for recovery.
A I Qureshi; A A Cook; H P Mishu; D A Krendel
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Muscle & nerve     Volume:  20     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-26     Completed Date:  1997-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1002-7     Citation Subset:  IM; X    
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*,  immunology
Immunocompromised Host*
Polyradiculoneuropathy / complications*,  immunology

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