Document Detail

Guillain-Barré syndrome during treatment with interferon alpha for hepatitis B.
MedLine Citation:
PMID:  15177399     Owner:  NLM     Status:  MEDLINE    
We describe a patient who developed acute demyelinating polyneuropathy on the sixth week of interferon (IFN)alpha therapy for chronic hepatitis B (HBV) infection. A 23-year-old man with chronic HBV infection had acute onset of demyelinating polyneuropathy shortly after completing a standard 6-week course of therapy with IFNalpha 2a. Clinical findings, electrodiagnostic studies and elevated cerebrospinal fluid protein levels without cells supported the diagnosis of Guillain-Barré syndrome (GBS). Other potential causes of GBS were ruled out. It remains unknown whether IFNalpha or the HBV infection itself was the cause of GBS, but it is evident that IFNalpha could not have prevented the development of GBS in our patient. We suggest that coexistent HBV infection and IFNalpha therapy may play a role in triggering an autoimmune response to peripheral nerve myelin.
Cavit Boz; Mehmet Ozmenoglu; Gonulden Aktoz; Sibel Velioglu; Zekeriya Alioglu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  11     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-04     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  523-5     Citation Subset:  IM    
Department of Neurology, Medical Faculty of Karadeniz Technical University, Trabzon, Turkey.
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MeSH Terms
Antiviral Agents / adverse effects*
Guillain-Barre Syndrome / chemically induced*,  physiopathology
Hepatitis B / drug therapy
Interferon-alpha / adverse effects*
Neural Conduction / drug effects,  physiology
Reaction Time / drug effects
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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