| Guillain-Barré syndrome associated with minimal change glomerulopathy and tubular dysfunction - related to acetone-based organic solvent? | |
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MedLine Citation:
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PMID: 12381959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 55-year-old woman presented with Guillain-Barré syndrome, nephrotic syndrome and multiple tubular dysfunction under occupational exposure to an organic solvent, which contained acetone as the principal solvent. In this case, the onset of the nephrotic syndrome and tubular dysfunction coincided with the development of the neurological manifestation. Renal biopsy demonstrated minimal change glomerulopathy with moderate tubulointerstitial nephritis. Several clearance tests that evaluated tubular transport functions revealed multiple tubular defects (including the Na(+)-K(+)-Cl(-) cotransporter of thick ascending limb and distal proton pump). The simultaneous occurrence of Guillain-Barré and nephrotic syndrome has previously been reported. However, both minimal glomerulopathy with multiple tubular dysfunction and progressive peripheral neuropathy under occupational exposure to an organic solvent remain unreported. Herein, we presented a rare association of minimal change nephrotic syndrome, tubular dysfunction with Guillain-Barré syndrome under the risk of exposure to an acetone-based cleansing solution; the case raises our concerns about possible chronic nephrotoxic or neurotoxic effects of common chemical organic solvents. |
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Authors:
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Jiann-Keh Chen; Mai-Szu Wu; Chih-Wei Yang; Jeng-Yi Huang; Po-Yaur Hsu; Chun-Liang Lin; Chiu-Ching Huang |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of nephrology Volume: 22 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2002 Sep-Dec |
Date Detail:
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Created Date: 2002-10-16 Completed Date: 2003-03-03 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 560-5 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
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poisoning* Female Guillain-Barre Syndrome / chemically induced*, complications Humans Middle Aged Nephritis, Interstitial / chemically induced Nephrosis, Lipoid / chemically induced*, complications Occupational Exposure* Solvents / poisoning* |
| Chemical | |
Reg. No./Substance:
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0/Solvents; 67-64-1/Acetone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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