Document Detail


Guillain-Barre syndrome: etiology and pathogenesis
MedLine Citation:
PMID:  12415961     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Guillain-Barre syndrome (GBS) is a reactive, self-limited, monophasic disease triggered by a preceding bacterial or viral infection. GBS has also been linked to underlying systemic diseases, certain malignancies, surgery, pregnancy, trauma severe infection, and tissue transplantation (bone marrow and organs). Although its pathogenesis is unclear, it is likely to be a consequence of an immune mediated process. Therefore, we believe that GBS results from an aberrant immune response that somehow mistakenly attacks the nerve tissue of its host, most probably by recognizing a molecular similar epitope mechanism (molecular mimicry). Immune reactions against these epitopes result in acute inflammatory demyelinating neuropathy or acute axonal forms. GBS has a worldwide distribution with an annual incidence of approximately 1.2-8.6 cases per 100,000 people. Both genders are at similar risk (but there is a slight male predominance). All ages are affected, although the distribution is bimodal. The supporting measures are critically important to provide optimal treatment. Immunomodulation with plasma exchange and intravenous immunoglobulin treatments shorten the disease course. Outcome is generally good, with virtually full recovery in 70-80% of the patients. In this review physiopathological aspects and clinical implications of GBS are fully discussed.
Authors:
José Alberto Avila-Funes; Vitelio Augusto Mariona-Montero; Efrén Melano-Carranza
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición     Volume:  54     ISSN:  0034-8376     ISO Abbreviation:  Rev. Invest. Clin.     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-11-05     Completed Date:  2003-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421552     Medline TA:  Rev Invest Clin     Country:  Mexico    
Other Details:
Languages:  spa     Pagination:  357-63     Citation Subset:  IM    
Affiliation:
Departamento de Medicina Interna, del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga # 15, Col. Sección XVI Tialpan, México, D.F., 14080. avilaf1@hotmail.com
Vernacular Title:
Síndrome de Guillain-Barré: etiología y patogénesis.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Antigens, Bacterial / immunology
Antigens, Viral / immunology
Autoantigens / immunology
Autoimmune Diseases / diagnosis,  epidemiology,  etiology*,  immunology,  therapy
Child
Child, Preschool
Epitopes / immunology
Female
Gangliosides / immunology
Guillain-Barre Syndrome / diagnosis,  epidemiology,  etiology*,  immunology,  therapy
Humans
Immune System / physiopathology
Immunoglobulins, Intravenous / therapeutic use
Incidence
Infant
Infection / complications,  immunology
Inflammation / complications,  immunology
Male
Middle Aged
Molecular Mimicry
Neuritis, Autoimmune, Experimental / etiology
Plasma Exchange
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, Viral; 0/Autoantigens; 0/Epitopes; 0/Gangliosides; 0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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