| Guillain-Barré syndrome mimicking acute methotrexate-associated encephalopathy in an adolescent patient with lymphoblastic lymphoma. | |
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MedLine Citation:
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PMID: 20463610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe an adolescent case of Guillain-Barré syndrome (GBS) mimicking acute methotrexate-associated encephalopathy during chemotherapy for lymphoblastic lymphoma. Although initial presentations of hemiparesis and irritability were suggestive of acute encephalopathy, the diminished deep tendon reflexes and subsequent rapid progression to flaccid triparesis with bulbar palsy were consistent with GBS. After the initiation of intravenous immunoglobulin therapy her symptoms improved rapidly, and the diagnosis of GBS was confirmed by nerve conduction studies and cerebrospinal fluid examination in recovery phase. GBS should be considered in the differential diagnosis of acute methotrexate-associated encephalopathy, although GBS is a rare neurologic complication. |
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Authors:
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Kiminori Terui; Yoshihiro Takahashi; Shinya Sasaki; Ko Kudo; Takuya Kamio; Etsuro Ito |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2010-11-16 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 615-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan. teru@cc.hirosaki-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antimetabolites, Antineoplastic / administration & dosage*, adverse effects Brain Diseases / chemically induced*, diagnosis* Diagnosis, Differential Female Guillain-Barre Syndrome / diagnosis* Humans Methotrexate / administration & dosage*, adverse effects Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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