Document Detail

Guiding ligands to nuclear receptors.
MedLine Citation:
PMID:  17512397     Owner:  NLM     Status:  MEDLINE    
Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively.
Liliane Michalik; Walter Wahli
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Cell     Volume:  129     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-51     Citation Subset:  IM    
Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Switzerland.
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MeSH Terms
Active Transport, Cell Nucleus / physiology
Apoptosis / physiology
Cell Nucleus / metabolism*
Cell Survival / physiology
PPAR-beta / metabolism*
Receptors, Retinoic Acid / metabolism*
Signal Transduction / physiology*
Tretinoin / metabolism*
Reg. No./Substance:
0/Ligands; 0/PPAR-beta; 0/Receptors, Retinoic Acid; 302-79-4/Tretinoin
Comment On:
Cell. 2007 May 18;129(4):723-33   [PMID:  17512406 ]

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