| Guiding ligands to nuclear receptors. | |
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MedLine Citation:
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PMID: 17512397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively. |
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Authors:
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Liliane Michalik; Walter Wahli |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: Cell Volume: 129 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-21 Completed Date: 2007-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 649-51 Citation Subset: IM |
Affiliation:
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Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Active Transport, Cell Nucleus
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physiology Animals Apoptosis / physiology Cell Nucleus / metabolism* Cell Survival / physiology Humans Ligands PPAR-beta / metabolism* Receptors, Retinoic Acid / metabolism* Signal Transduction / physiology* Tretinoin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/PPAR-beta; 0/Receptors, Retinoic Acid; 302-79-4/Tretinoin |
| Comments/Corrections | |
Comment On:
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Cell. 2007 May 18;129(4):723-33
[PMID:
17512406
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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