| Guidewire flow obstruction effect on pressure drop-flow relationship in moderate coronary artery stenosis. | |
| | |
MedLine Citation:
|
PMID: 16488224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To evaluate the local hemodynamic effects of coronary artery balloon angioplasty, computational fluid dynamics was applied to representative stenoses geometry post-angioplasty (minimal lesion diameter d(m) = 1.8mm which produced 64% mean area stenoses) based on a group of patients and measured values of coronary flow reserve (CFR) returning to a normal range (3.6+/-0.3). The computations were at mean flow rates (Q) of 50, 100, 150 and 170 ml/min. The study indicates changes in the hemodynamic conditions due to insertion of a guidewire, which can be used to determine the mean pressure drop (Deltap ) and fall in distal mean coronary pressure (p(r)), and thus give quantitative estimate of uncertainty expected in diagnosis of moderate lesions. The guidewire to minimal lesion diameter ratio is 0.26, causing tighter "artifactual" mean area stenoses of 65.5%. During hyperemia, p(m) dropped to 72 mmHg as compared to 75 mmHg under patho-physiological condition without guidewire. Q(h) (subscript h: hyperemia) decreased from 180 without guidewire to 170 ml/min with the guidewire present. Thus, there was a significant approximately 43% increase in Deltap(h) and a approximately 51% increase in the hyperemic flow resistance (R(h) = Deltap(h)/Q(h)) over the patho-physiological condition. This could cause an overestimation of the severity of the moderate stenoses. Transient and steady flow guidewire surface shear stress was 35-50% higher than corresponding values for arterial wall shear stress. The non-dimensional data given in tabular form may be useful in interpretation of clinical guidewire measurements for moderate lesions of similar geometry and size. |
| | |
Authors:
|
Abhijit Sinha Roy; Lloyd H Back; Rupak K Banerjee |
Related Documents
:
|
12641024 - Rationale of combined intracoronary pressure and flow velocity measurements. 2952824 - Effects of treadmill and pacing stress testing on peripheral arterial thromboxane, plat... 1762514 - Characterization of the coronary vascular responses to platelet-activating factor in th... 14740694 - Perioperative infarction: effects of cardiopulmonary bypass on collateral circulation i... 3177684 - Acute changes in forearm venous volume and tone using radionuclide plethysmography. 21860634 - The significance of the j-curve in hypertension and coronary artery diseases. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of biomechanics Volume: 39 ISSN: 0021-9290 ISO Abbreviation: J Biomech Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-02-20 Completed Date: 2006-06-29 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
|
Languages: eng Pagination: 853-64 Citation Subset: IM |
Affiliation:
|
Department of Mechanical Engineering, University of Cincinnati, 688 Rhodes Hall, PO Box 210072, Cincinnati, OH 45221-0072, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Transluminal, Percutaneous Coronary
/
instrumentation*,
methods* Blood Flow Velocity Blood Pressure Computer Simulation Coronary Stenosis / physiopathology*, surgery* Humans Models, Cardiovascular* Prognosis Severity of Illness Index Surgery, Computer-Assisted / methods Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analysis of skin movement with respect to flexional bone motion using MR images of a hand.
Next Document: Comparing two estimations of the quadriceps force distribution for use during patellofemoral simulat...