Document Detail

Guidelines for pregnancy: What's an acceptable risk, and how is the evidence (finally) shaping up?
MedLine Citation:
PMID:  21955332     Owner:  NLM     Status:  Publisher    
Issues. The lack of consensus about whether low to moderate levels of prenatal alcohol exposure are a risk factor for fetal development has generated considerable debate about what advice policies and guidelines should provide. Approach. This paper reviews the evidence from systematic reviews and meta-analyses examining the risk from low and moderate levels of prenatal alcohol exposure, along with the results of articles published 2009-2010, after the reviews. Key Findings. The reported significant effects from low levels of prenatal alcohol exposure are likely due to methodological issues such as confounding and/or misclassification of exposure or outcome and there is no strong research evidence of fetal effects from low levels of alcohol exposure. However, harm is well-documented with heavy exposure and moderate levels of exposure, 30-40 g per occasion and no more than 70 g per week, have been demonstrated to increase the risk of child behaviour problems. Implications. With such a small margin before there is increased risk to the fetus, it would be morally and ethically unacceptable for policies and guidelines to condone consumption of alcohol during pregnancy. Not all women will follow this advice and some women will inadvertently consume alcohol prior to pregnancy awareness requiring non-judgmental counselling and the provision of rational advice about the likelihood of risk to the fetus. Conclusions. The policy advice that 'the safest choice for pregnant women is to abstain from alcohol during pregnancy' should be maintained. However, the abstinence message needs to be presented in a balanced and rational manner to prevent unintended negative consequences.[O'Leary CM, Bower C. Guidelines for pregnancy: What's an acceptable risk, and how is the evidence (finally) shaping up? Drug Alcohol Rev 2011].
Colleen M O'Leary; Carol Bower
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-29
Journal Detail:
Title:  Drug and alcohol review     Volume:  -     ISSN:  1465-3362     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015440     Medline TA:  Drug Alcohol Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Australasian Professional Society on Alcohol and other Drugs.
National Drug Research Institute, Curtin University, Perth, Australia Division of Population Sciences, Telethon Institute for Child Health Research, Perth, Australia Centre for Child Health Research, University of Western Australia, Perth, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quality of medical devices and in vitro diagnostics in resource-limited settings.
Next Document:  4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors o...