Document Detail

Guidelines for the management of ovarian cancer during pregnancy.
MedLine Citation:
PMID:  20042265     Owner:  NLM     Status:  MEDLINE    
Adnexal masses may be detected during prenatal ultrasound, and ovarian cancer may be suspected during pregnancy. Even though such masses are rarely malignant (1/10,000 to 1/50,000 pregnancies), the possibility of borderline tumour or cancer must be considered. It is a common assumption by both patients and physicians that if an ovarian cancer is diagnosed during pregnancy, treatment necessitates sacrificing the well-being of the fetus. However, in most cases, it is possible to offer appropriate treatment to the mother without placing the fetus at serious risk. The care of a pregnant woman with cancer involves evaluation of sometimes competing maternal and fetal risks and benefits. These recommendations attempt to balance these risks and benefits; however, they should be considered advisory and should not replace specific interdisciplinary consultation with specialists in maternal-fetal medicine, gynecologic oncology and pediatrics, as well as imaging and pathology, as needed. Second level ultrasound including Doppler is needed. MRI is not often necessary, and CA 125 is of low contribution. We suggest surgery be performed after 15 weeks gestation for ovarian masses which (1) persist into the second trimester, (2) are greater than 5-10 cm in diameter, or (3) have solid or mixed solid and cystic ultrasound characteristics. During the antepartum period surgical staging and debulking, unilateral salpingo-oophorectomy on the side with the tumour, peritoneal cytology and exploration are necessary. Women found to have advanced stage epithelial ovarian cancer should consider having completion of the debulking of the reproductive organs at the conclusion of the pregnancy. If chemotherapy is indicated, we recommend delaying administration, if possible, until after the delivery or at least after 20 weeks in order to minimize the potential fetal toxicity.
Henri Marret; Catherine Lhomm?; Fabrice Lecuru; Michel Canis; Jean L?v?que; Francois Golfier; Philippe Morice
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-12-29
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  149     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  18-21     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Centre Hospitalier Regionale et Universitaire de Tours, H?pital Bretonneau, Department of Gynaecology and Obstetrics, Foetal Medicine, Medicine and Reproductive Biology, Tours 37044 c?dex 1, France.
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MeSH Terms
Guidelines as Topic
Ovarian Neoplasms / diagnosis,  therapy*
Pregnancy Complications, Neoplastic / diagnosis,  therapy*
Ultrasonography, Prenatal

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