Document Detail

Guided tissue regeneration combined with a deproteinized bovine bone mineral (Bio-Oss) in the treatment of intrabony periodontal defects: 6-year results from a randomized-controlled clinical trial.
MedLine Citation:
PMID:  20653820     Owner:  NLM     Status:  MEDLINE    
AIM: To present the 6-year results of a randomized-controlled clinical trial evaluating guided tissue regeneration (GTR) combined with or without deproteinized bovine bone mineral (DBBM) in intrabony defects.
MATERIAL & METHODS: In each of 45 patients, one defect was treated with GTR combined with DBBM hydrated in saline (DBBM-) or gentamicin sulphate (DBBM+) or with GTR alone. Clinical parameters were recorded pre-surgery, at 1 and 6 years postsurgery.
RESULTS: Thirty-six patients/33 teeth were available for the 6-year control. Statistically significant clinical improvements were observed for all treatments. Clinical attachment level (CAL) gain averaged 2.5 mm (DBBM-), 4.1 mm (DBBM+), and 3.0 mm (GTR) at 1 year postsurgery, and remained stable over 5 additional years (2.3, 4.1, and 2.7 mm, respectively). Treatment did not appear to influence residual probing depths (PDs) or CAL gains at 6 years postsurgery, or the extent of PD and CAL change from 1 to 6 years, and did not associate with sites losing CAL during follow-up. No association of grafting with sites showing CAL gain >or=4 mm at the 1- or 6-year control was observed.
CONCLUSION: The improvements in periodontal conditions obtained after GTR treatment with or without the adjunct use of DBBM can be preserved on a long-term basis.
Andreas Stavropoulos; Thorkild Karring
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  37     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  200-10     Citation Subset:  D; IM    
Department of Periodontology and Oral Gerontology, School of Dentistry, University of Aarhus, Aarhus, Denmark.
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MeSH Terms
Absorbable Implants
Alveolar Bone Loss / radiography,  therapy*
Biocompatible Materials
Bone Matrix / transplantation
Bone Regeneration / drug effects*
Bone Substitutes / therapeutic use*
Combined Modality Therapy
Guided Tissue Regeneration, Periodontal / methods*
Linear Models
Middle Aged
Minerals / therapeutic use*
Periodontal Attachment Loss / radiography,  therapy
Treatment Outcome
Reg. No./Substance:
0/Bio-Oss; 0/Biocompatible Materials; 0/Bone Substitutes; 0/Minerals

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