| Guided e-MRI prostate biopsy can solve the discordance between Gleason score biopsy and radical prostatectomy pathology. | |
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MedLine Citation:
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PMID: 20418041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The aim of this study is to examine if guided prostate biopsies based on abnormalities detected by conventional and functional endorectal magnetic resonance imaging (MRI) yield a more reliable representation of the radical prostatectomy pathology and to identify probable preoperative clinical variables that stratified patients likely to harbor significant upgrading. PATIENTS AND METHODS: From April 2004 to April 2009, a review of N=70 patients records diagnosed with prostate cancer by a 3-6 core guided transrectal ultrasound (TRUS) prostate biopsy based on abnormalities detected by conventional and functional endorectal MRI and who subsequently underwent radical prostatectomy and exhibited a significant upgrading was conducted. Additionally, a multivariate analysis with a significant upgrading as the outcome was performed including the following parameters: prostate specific antigen (PSA) level, clinical stage, prostate size and duration from biopsy to radical prostatectomy. RESULTS: A significant upgrading was noted in only 8.5% of patients, with 1.4% exhibiting a significant downgrading and the rest 90.1% exhibiting an exact Gleason score match. No preoperative clinical variables that stratified patients likely to harbour significant upgrading were identified. CONCLUSIONS: This type of biopsy method seems to solve the discordance between the biopsy Gleason score and radical prostatectomy pathology regardless of known preoperative clinical variables that can affect it. |
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Authors:
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Apostolos P Labanaris; Vahudin Zugor; Robert Smiszek; Reinhold Nützel; Reinhard Kühn; Karl Engelhard |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-04-24 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 28 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 943-6 Citation Subset: IM |
Affiliation:
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Department of Urology, Martha Maria Medical Center, Academic Hospital of Erlangen University, Nurnberg, Germany. Labanaris@web.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy, Needle
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methods* Feasibility Studies Humans Magnetic Resonance Imaging / methods* Male Prostatectomy* Prostatic Neoplasms / pathology*, surgery* Reproducibility of Results Sensitivity and Specificity Surgery, Computer-Assisted / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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