Document Detail

Guided bone regeneration of cranial defects, using biodegradable barriers: an experimental pilot study in the rabbit.
MedLine Citation:
PMID:  1401099     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to test if a biodegradable barrier could be used to achieve proper bone healing of full-thickness trephine skull defects, applying the biological principle of guided tissue regeneration (GTR). Two New Zealand white rabbits were used. In each animal, 2 circular through-and-through bone defects with a diameter of 8 mm were created in the midline of the frontal and parietal bones of the calvarium. One defect was covered with the mucoperiosteal flaps without placement of an intervening membrane barrier (control). One test defect (test 1) was covered by a biodegradable, non-porous polylactic acid membrane on the outer (supra-calvarial) side of the defect, and 2 test defects (tests 2 and 3) were covered by similar membranes on both the outer and the inner aspects of the defects, prior to flap closure. 6 weeks postsurgically, the animals were sacrificed and the defect areas including surrounding tissues were harvested for histological preparation. The control defect was essentially occupied by supra-calvarial soft tissue, located in direct contact with the dural tissue. In the test cavities, there was a continuous bridge of regenerated bone extending from one edge of the defect to the other, although in test 1 not attaining the same thickness as the bone bordering the defect. In the 2 other test defects, the regenerated bone had reached a thickness almost corresponding to that of the surrounding bone. The bone regeneration was achieved without recourse to adjunctive bone graft materials.(ABSTRACT TRUNCATED AT 250 WORDS)
D Lundgren; S Nyman; T Mathisen; S Isaksson; B Klinge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery     Volume:  20     ISSN:  1010-5182     ISO Abbreviation:  J Craniomaxillofac Surg     Publication Date:    1992 Aug-Sep
Date Detail:
Created Date:  1992-10-28     Completed Date:  1992-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8704309     Medline TA:  J Craniomaxillofac Surg     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  D; IM    
Dept. of Periodontology, Institute for Postgraduate Dental Education, Jönköping, Sweden.
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MeSH Terms
Biodegradation, Environmental
Bone Regeneration*
Guided Tissue Regeneration*
Membranes, Artificial
Pilot Projects
Skull / pathology,  physiopathology*
Reg. No./Substance:
0/Membranes, Artificial

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