| Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. | |
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MedLine Citation:
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PMID: 23359576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother's previous immunity to HSV. Women with primary genital HSV infections who are shedding HSV at delivery are 10 to 30 times more likely to transmit the virus to their newborn infants than are women with recurrent HSV infection who are shedding virus at delivery. With the availability of commercial serological tests that reliably can distinguish type-specific HSV antibodies, it is now possible to determine the type of maternal infection and, thus, further refine management of infants delivered to women who have active genital HSV lesions. The management algorithm presented herein uses both serological and virological studies to determine the risk of HSV transmission to the neonate who is delivered to a mother with active herpetic genital lesions and tailors management accordingly. The algorithm does not address the approach to asymptomatic neonates delivered to women with a history of genital herpes but no active lesions at delivery. |
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Authors:
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David W Kimberlin; Jill Baley; ; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2013-01-28 |
Journal Detail:
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Title: Pediatrics Volume: 131 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-04 Completed Date: 2013-04-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e635-46 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyclovir
/
administration & dosage,
adverse effects,
analogs & derivatives*,
therapeutic use* Algorithms Antiviral Agents / therapeutic use* Asymptomatic Infections* Cesarean Section Drug Administration Schedule Female Guideline Adherence Herpes Genitalis / diagnosis, drug therapy*, transmission* Humans Infant, Newborn Infectious Disease Transmission, Vertical* Infusions, Intravenous Pregnancy Pregnancy Complications, Infectious / diagnosis, drug therapy* Recurrence / prevention & control Risk Valine / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Virus Activation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00032/RR/NCRR NIH HHS; N01-AI-15113/AI/NIAID NIH HHS; N01-AI-30025/AI/NIAID NIH HHS; N01-AI-62554/AI/NIAID NIH HHS; N01-AI-65306/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 59277-89-3/Acyclovir; 7004-03-7/Valine; MZ1IW7Q79D/valacyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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