Document Detail


Guidance on management of asymptomatic neonates born to women with active genital herpes lesions.
MedLine Citation:
PMID:  23359576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Herpes simplex virus (HSV) infection of the neonate is uncommon, but genital herpes infections in adults are very common. Thus, although treating an infant with neonatal herpes is a relatively rare occurrence, managing infants potentially exposed to HSV at the time of delivery occurs more frequently. The risk of transmitting HSV to an infant during delivery is determined in part by the mother's previous immunity to HSV. Women with primary genital HSV infections who are shedding HSV at delivery are 10 to 30 times more likely to transmit the virus to their newborn infants than are women with recurrent HSV infection who are shedding virus at delivery. With the availability of commercial serological tests that reliably can distinguish type-specific HSV antibodies, it is now possible to determine the type of maternal infection and, thus, further refine management of infants delivered to women who have active genital HSV lesions. The management algorithm presented herein uses both serological and virological studies to determine the risk of HSV transmission to the neonate who is delivered to a mother with active herpetic genital lesions and tailors management accordingly. The algorithm does not address the approach to asymptomatic neonates delivered to women with a history of genital herpes but no active lesions at delivery.
Authors:
David W Kimberlin; Jill Baley; ;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-28
Journal Detail:
Title:  Pediatrics     Volume:  131     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-04-11     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e635-46     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acyclovir / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use*
Algorithms
Antiviral Agents / therapeutic use*
Asymptomatic Infections*
Cesarean Section
Drug Administration Schedule
Female
Guideline Adherence
Herpes Genitalis / diagnosis,  drug therapy*,  transmission*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical*
Infusions, Intravenous
Pregnancy
Pregnancy Complications, Infectious / diagnosis,  drug therapy*
Recurrence / prevention & control
Risk
Valine / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Virus Activation / drug effects
Grant Support
ID/Acronym/Agency:
M01-RR00032/RR/NCRR NIH HHS; N01-AI-15113/AI/NIAID NIH HHS; N01-AI-30025/AI/NIAID NIH HHS; N01-AI-62554/AI/NIAID NIH HHS; N01-AI-65306/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; HG18B9YRS7/Valine; MZ1IW7Q79D/valacyclovir; X4HES1O11F/Acyclovir
Comments/Corrections

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