| Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells. | |
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MedLine Citation:
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PMID: 20651339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Guggulsterone, a plant polyphenol guggulipid, has several antitumour effects and acts as an antagonist for the farnesoid X receptor. Although bile acids induce caudal-related homeobox 2 (CdX2), a transcription factor essential for intestinal development and gut tumourigenesis, the effects of guggulsterone on regulation of CdX2 in the gut are unknown. MATERIALS AND METHODS: Regulation of CdX2 expression by treatment with bile acids and/or guggulsterone was analysed by immunoblot analysis in human gut-derived adenocarcinoma, Bic-1 cells. Nuclear factor-kappaB (NF-kappaB) activity and the cell cycle distribution were also examined. RESULTS: Chenodeoxycholic acid and deoxycholic acid increased CdX2 expression in Bic-1 cells. Guggulsterone reduced bile acid-induced and constitutive CdX2 expression at 5 microM. Guggulsterone (up to 5 microM) did not affect cell viability or the cell cycle and did not attenuate bile acid-induced or constitutive NF-kappaB activation. CONCLUSION: Guggulsterone may be used as a novel drug to target CdX2 expression in certain gut adenocarcinomas. |
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Authors:
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Takanori Yamada; Satoshi Osawa; Yasushi Hamaya; Takahisa Furuta; Akira Hishida; Masayoshi Kajimura; Mutsuhiro Ikuma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 1953-60 Citation Subset: IM |
Affiliation:
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First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy*,
pathology Antineoplastic Agents, Phytogenic / pharmacology* Apoptosis / drug effects Bile Acids and Salts / antagonists & inhibitors* Cell Cycle / drug effects Cell Line, Tumor Cell Survival / drug effects Homeodomain Proteins / antagonists & inhibitors* Humans Intestinal Neoplasms / drug therapy*, pathology NF-kappa B / antagonists & inhibitors, metabolism Pregnenediones / pharmacology* Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Bile Acids and Salts; 0/CDX2 protein, human; 0/Homeodomain Proteins; 0/NF-kappa B; 0/Pregnenediones; 0/Receptors, Cytoplasmic and Nuclear; 0/farnesoid X-activated receptor; 95975-55-6/pregna-4,17-diene-3,16-dione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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