Document Detail


Guardian of corpulence: a hypothesis on p53 signaling in the fat cell.
MedLine Citation:
PMID:  20126301     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Adipocytes provide an organism with fuel in times of caloric deficit, and are an important type of endocrine cell in the maintenance of metabolic homeostasis. In addition, as a lipid-sink, adipocytes serve an equally important role in the protection of organs from the damaging effects of ectopic lipid deposition. For the organism, it is of vital importance to maintain adipocyte viability, yet the fat depot is a demanding extracellular environment with high levels of interstitial free fatty acids and associated lipotoxic effects. These surroundings are less than beneficial for the overall health of any resident cell, adipocyte and preadipocyte alike. In this review, we discuss the process of adipogenesis and the potential involvement of the p53 tumor-suppressor protein in alleviating some of the cellular stress experienced by these cells. In particular, we discuss p53-mediated mechanisms that prevent damage caused by reactive oxygen species and the effects of lipotoxicity. We also suggest the potential for two p53 target genes, START domain-containing protein 4 (StARD4) and oxysterol-binding protein (OSBP), with the concomitant synthesis of the signaling molecule oxysterol, to participate in adipogenesis.
Authors:
Merlijn Bazuine; Karin G Stenkula; Maggie Cam; Mathilde Arroyo; Samuel W Cushman
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Clinical lipidology     Volume:  4     ISSN:  1758-4302     ISO Abbreviation:  -     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2010-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101502551     Medline TA:  Clin Lipidol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  231-243     Citation Subset:  -    
Affiliation:
Experimental Diabetes, Metabolism & Nutrition Section, Diabetes Branch, NIDDK, NIH, Building 10-CRC, Room 5W-5816, 10 Center Drive, Bethesda, MD 20892, USA, Tel.: +1 301 496 7354, , bazuinem@niddk.nih.gov.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
NIH0011646659//PHS HHS; Z01 DK075014-02//NIDDK NIH HHS

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