| Guar gum reduces postprandial hypotension in older people. | |
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MedLine Citation:
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PMID: 11207870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether slowing of gastric emptying and glucose absorption with guar gum would reduce the fall in blood pressure after an oral glucose load in older subjects. DESIGN: A randomized, experimental, cross-over study. SETTING: Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia. PARTICIPANTS: Ten healthy subjects, age 67 to 78. MEASUREMENTS: Simultaneous measurements of gastric emptying, blood pressure, blood glucose, serum insulin, and oral glucose absorption (3-O-methyl-D-glucose [3-OMG]) on two occasions after ingestion of 300 mL water containing 50 g glucose and 30 mL lemon juice, 3 g 3-OMG labeled with 99mTc-sulphur colloid; with or without 9 g guar gum. Blood pressure and gastric emptying were monitored for 180 minutes. RESULTS: The magnitude of the falls in systolic (P = .02), diastolic (P < .05), and mean arterial (P = .05) blood pressure were less, and gastric emptying slower (P < .05), after guar. Blood glucose, insulin, and 3-OMG concentrations were reduced (P < .001 for all) by guar. 3-OMG concentrations were inversely related to the intragastric retention of glucose (r = -0.72, P = .02) and blood pressure was inversely related to 3-OMG (r = -0.64, P < .05) after the drink without guar. The blood glucose concentration was related to 3-OMG (r > 0.64, P < .05). CONCLUSION: Guar gum reduces the magnitude of the fall in blood pressure after oral glucose. Slowing of gastric emptying and glucose absorption may represent a novel approach to the treatment of postprandial hypotension. |
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Authors:
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K L Jones; C MacIntosh; Y C Su; F Wells; I M Chapman; A Tonkin; M Horowitz |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 49 ISSN: 0002-8614 ISO Abbreviation: J Am Geriatr Soc Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-03-29 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: United States |
Other Details:
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Languages: eng Pagination: 162-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Royal Adelaide Hospital, University of Adelaide, South Australia, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Analysis of Variance Blood Glucose / drug effects Blood Pressure / drug effects Cross-Over Studies Diastole / drug effects Drug Monitoring Female Galactans / pharmacology, therapeutic use* Gastric Emptying / drug effects Humans Hypotension / etiology*, metabolism, prevention & control* Insulin / blood Intestinal Absorption / drug effects Linear Models Male Mannans / pharmacology, therapeutic use* Plant Gums Postprandial Period / drug effects* Systole / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Galactans; 0/Mannans; 0/Plant Gums; 11061-68-0/Insulin; 9000-30-0/guar gum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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