Document Detail

Guar gum reduces postprandial hypotension in older people.
MedLine Citation:
PMID:  11207870     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether slowing of gastric emptying and glucose absorption with guar gum would reduce the fall in blood pressure after an oral glucose load in older subjects. DESIGN: A randomized, experimental, cross-over study. SETTING: Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia. PARTICIPANTS: Ten healthy subjects, age 67 to 78. MEASUREMENTS: Simultaneous measurements of gastric emptying, blood pressure, blood glucose, serum insulin, and oral glucose absorption (3-O-methyl-D-glucose [3-OMG]) on two occasions after ingestion of 300 mL water containing 50 g glucose and 30 mL lemon juice, 3 g 3-OMG labeled with 99mTc-sulphur colloid; with or without 9 g guar gum. Blood pressure and gastric emptying were monitored for 180 minutes. RESULTS: The magnitude of the falls in systolic (P = .02), diastolic (P < .05), and mean arterial (P = .05) blood pressure were less, and gastric emptying slower (P < .05), after guar. Blood glucose, insulin, and 3-OMG concentrations were reduced (P < .001 for all) by guar. 3-OMG concentrations were inversely related to the intragastric retention of glucose (r = -0.72, P = .02) and blood pressure was inversely related to 3-OMG (r = -0.64, P < .05) after the drink without guar. The blood glucose concentration was related to 3-OMG (r > 0.64, P < .05). CONCLUSION: Guar gum reduces the magnitude of the fall in blood pressure after oral glucose. Slowing of gastric emptying and glucose absorption may represent a novel approach to the treatment of postprandial hypotension.
K L Jones; C MacIntosh; Y C Su; F Wells; I M Chapman; A Tonkin; M Horowitz
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  49     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-03-29     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-7     Citation Subset:  IM    
Department of Medicine, Royal Adelaide Hospital, University of Adelaide, South Australia, Australia.
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MeSH Terms
Age Factors
Analysis of Variance
Blood Glucose / drug effects
Blood Pressure / drug effects
Cross-Over Studies
Diastole / drug effects
Drug Monitoring
Galactans / pharmacology,  therapeutic use*
Gastric Emptying / drug effects
Hypotension / etiology*,  metabolism,  prevention & control*
Insulin / blood
Intestinal Absorption / drug effects
Linear Models
Mannans / pharmacology,  therapeutic use*
Plant Gums
Postprandial Period / drug effects*
Systole / drug effects
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Galactans; 0/Mannans; 0/Plant Gums; 11061-68-0/Insulin; 9000-30-0/guar gum

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