| Guanxin II (II) for the management of coronary heart disease. | |
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MedLine Citation:
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PMID: 20082256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This article presents an integrated overview of Guanxin II (II) regarding its quality control, pharmacokinetics, pharmacology, clinical studies, adverse events, dosage and administration, and its pharmacoeconomic assessment. It has been demonstrated that Guanxin II has beneficial effects on coronary heart disease (CHD). The underlying mechanism was proved to be its anti-ischemic, anti-apoptotic, antioxidative, antiplatelet and anti-inflammatory effects, and so on. Tanshinol, hydroxysafflor yellow A and ferulic acid might be responsible for the cardioprotective effect of Guanxin II. In terms of acquisition cost, Guanxin II is cheaper than other drugs currently available for CHD. Guanxin II is safe, cheap, and effective in the management of CHD. However, the mechanism of its cardioprotective effects has not been completely understood because of limitations in the research methodologies of Chinese medicine. Further work should be carried out with single components such as tanshinol, hydroxysafflor yellow A and ferulic acid, using modern biochemical and molecular methods. |
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Authors:
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Feng Qin; Xi Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-18 |
Journal Detail:
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Title: Chinese journal of integrative medicine Volume: 15 ISSN: 1672-0415 ISO Abbreviation: Chin J Integr Med Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-18 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181180 Medline TA: Chin J Integr Med Country: China |
Other Details:
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Languages: eng Pagination: 472-6 Citation Subset: IM |
Affiliation:
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Department of Integrated Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Coronary Disease
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drug therapy* Drugs, Chinese Herbal / adverse effects, pharmacokinetics, pharmacology, therapeutic use* Economics, Pharmaceutical Humans |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/guanxin No. 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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