| 4(R/S)-Guanidinylprolyl collagen peptides: On-resin synthesis, complexation with plasmid DNA and the role of peptides in enhancment of transfection. | |
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MedLine Citation:
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PMID: 22428628 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chimeric collagen peptides containing cationic 4(R/S)-guanidinylproline are synthesized by in-situ amidinylation of 4(R/S)-aminoproline residues. These peptides uniquely enhance the transfection efficiency of GFP encoded plasmid DNA (pRmHa3-GFP) into cells through efficient DNA condensation resulting from non-specific electrostatic interactions of cationic guanidino groups and localise in sub-cytoplasmic organelles. |
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Authors:
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Manaswini Nanda; Krishna N Ganesh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-19 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: - ISSN: 1520-6904 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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