Document Detail


4(R/S)-Guanidinylprolyl collagen peptides: On-resin synthesis, complexation with plasmid DNA and the role of peptides in enhancment of transfection.
MedLine Citation:
PMID:  22428628     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chimeric collagen peptides containing cationic 4(R/S)-guanidinylproline are synthesized by in-situ amidinylation of 4(R/S)-aminoproline residues. These peptides uniquely enhance the transfection efficiency of GFP encoded plasmid DNA (pRmHa3-GFP) into cells through efficient DNA condensation resulting from non-specific electrostatic interactions of cationic guanidino groups and localise in sub-cytoplasmic organelles.
Authors:
Manaswini Nanda; Krishna N Ganesh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  -     ISSN:  1520-6904     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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