Document Detail

Guanidino compounds in uraemic dialysed patients.
MedLine Citation:
PMID:  3719996     Owner:  NLM     Status:  MEDLINE    
The concentrations of guanidino compounds in blood are raised in uraemic patients and may have toxic effects. The concentrations of 13 guanidino compounds in serum were measured in 29 patients with chronic renal failure treated by chronic intermittent haemodialysis using liquid cation exchange chromatography with a highly sensitive fluorescence detection method. For taurocyamine we used another column system. Substantial increases in guanidinosuccinic acid, creatine, N-alpha-acetylarginine, creatinine, guanidine and methylguanidine were found. The values obtained for taurocyamine and beta-guanidinoproprionic acid were much lower than those reported by others: a much smaller increase was observed for beta-guanidinoproprionic acid and taurocyamine was only doubled in 4 of 29 uraemic patients. The concentrations of other guanidino compounds such as arginine and guanidinoacetic acid were normal. No differences were found between the polycystic renal disease, the chronic glomerulonephritis and the interstitial nephritis subgroups.
P De Deyn; B Marescau; W Lornoy; I Becaus; A Lowenthal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  157     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-08-08     Completed Date:  1986-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
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MeSH Terms
Arginine / analogs & derivatives,  blood
Creatine / blood
Creatinine / blood
Guanidines / blood*
Methylguanidine / blood
Middle Aged
Renal Dialysis*
Succinates / blood
Uremia / blood*,  therapy
Reg. No./Substance:
0/Guanidines; 0/Succinates; 113-00-8/Guanidine; 155-84-0/N-acetyl-L-arginine; 471-29-4/Methylguanidine; 57-00-1/Creatine; 60-27-5/Creatinine; 6133-30-8/guanidinosuccinic acid; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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