Document Detail

Guanethidine-induced vasodilatation in the rabbit, mediated by endogenous histamine.
MedLine Citation:
PMID:  74267     Owner:  NLM     Status:  MEDLINE    
1 The effects of guanethidine (0.5-4 mg/kg i.v.) on arterial pressure, hindlimb blood flow and hindlimb vascular resistance (HVR) were studied in unanesthetized rabbits subjected to "total" autonomic block. 2 Evidence that this response was mediated by histamine release was that (a) 3H-labelled histamine levels in the hindlimb venous blood rose substantially after guanethidine; (b) infusion of exogenous histamine caused an inhibition of the guanethidine-induced vasodilatation; and (c) competitive antagonism of the response was obtained with the H2-antagonist burimamide. 3 There was good correlation between the [3H]-histamine ;elease and the time course of the vasodilator response. Glyceryl trinitrate infusions that lowered HVR substantially, did not cause release of histamine. 4 Reserpine, desipramine and indomethacin pretreatment did not alter the vasodilator response to guanethidine. 5 The guanethidine vasodilator response was not influenced by the H1-antagonist mepyramine or by the other H2-antagonists, metiamide or cimetidine. The vascular receptors stimulated by endogenous histamine may be distinctive from those stimulated by exogenous histamine, or the action of guanethidine may involve greater production of histamine at an intracellular site that is more readily reached by burimamide than by the other H2-antagonists.
J A Angus; A Bobik; P I Korner; M T Stoneham
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  62     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-03-29     Completed Date:  1978-03-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  7-17     Citation Subset:  IM    
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MeSH Terms
Desipramine / pharmacology
Drug Interactions
Guanethidine / pharmacology*
Hemodynamics / drug effects
Hindlimb / blood supply
Histamine / physiology*
Histamine Antagonists / pharmacology
Histamine Release / drug effects
Indomethacin / pharmacology
Mast Cells / drug effects
Nitroglycerin / pharmacology
Regional Blood Flow / drug effects
Reserpine / pharmacology
Vasodilation / drug effects*
p-Methoxy-N-methylphenethylamine / pharmacology
Reg. No./Substance:
0/Histamine Antagonists; 4091-50-3/p-Methoxy-N-methylphenethylamine; 50-47-5/Desipramine; 50-55-5/Reserpine; 51-45-6/Histamine; 53-86-1/Indomethacin; 55-63-0/Nitroglycerin; 55-65-2/Guanethidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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