Document Detail

Growth velocity during the first postnatal week of life is linked to a spurt of IGF-I effect.
MedLine Citation:
PMID:  12839540     Owner:  NLM     Status:  MEDLINE    
There is adequate evidence that growth during the perinatal period is linked to the risk of several adult onset diseases, and recent findings indicate that the insulin-like growth factor (IGF) system is involved in prenatal growth, as reflected in birthweight. However, whether major components of the IGF system are involved in the immediate post-natal growth has not been studied. Maternal questionnaires were completed, and laboratory measurements of several variables, including IGF-I, IGF-II and IGF-binding protein-3 (IGFBP-3), were made for a total of 331 apparently healthy full-term newborns, from whom routine blood samples were taken during the first 5 days of their life. Birthweight and weight at the time of bleeding were among the recorded variables, and the difference divided by the age in days of the newborn was considered as reflecting immediate postnatal growth velocity. Immediate postnatal growth velocity was strongly positively associated with IGF-I. The squared adjusted correlation coefficient was 0.29 when IGF-I was incorporated in the model predicting postnatal growth velocity but was only 0.08 when IGF-I was excluded. In contrast, IGF-II and IGFBP-3 had no effect on postnatal growth velocity. It thus appears that IGF-I underlies growth during the immediate postnatal period. To the extent that perinatal growth may affect adult onset diseases, the findings of this study suggest that the action of IGF-I during the immediate postnatal period may represent a process of major importance.
A Skalkidou; E Petridou; E Papathoma; H Salvanos; D Trichopoulos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  17     ISSN:  0269-5022     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-03     Completed Date:  2003-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece.
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MeSH Terms
Birth Weight
Infant, Newborn / growth & development*
Insulin-Like Growth Factor Binding Protein 3 / analysis
Insulin-Like Growth Factor I / analysis,  physiology*
Insulin-Like Growth Factor II / analysis
Regression Analysis
Weight Gain
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II
Comment In:
Paediatr Perinat Epidemiol. 2004 Sep;18(5):395   [PMID:  15367327 ]

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