Document Detail

Growth, tolerance and biochemical measures in healthy infants fed a partially hydrolyzed rice protein-based formula: a randomized, blinded, prospective trial.
MedLine Citation:
PMID:  16522927     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate growth, tolerance and plasma biochemistries in infants fed an experimental rice protein-based infant formula. DESIGN: Randomized, blinded, 16 week parallel feeding trial of 65 healthy infants fed either an experimental partially hydrolyzed rice protein-based infant formula fortified with lysine and threonine (RPF, n = 32), or a standard intact cow's milk protein-based formula (CMF, n = 33) as a control. Assessments occurred at enrollment (average 2 days), 2, 4, 8, and 16 weeks of age. RESULTS: Growth as indicated by weight, length, and head circumference was not different between the 2 formula groups. All plasma biochemistries for both groups were within reference normal range. However, RPF group had lower phosphorus and urea nitrogen, lower essential amino acids except threonine, which was higher, and lower ratio of essential (including semi-essential) to non-essential amino acids. Differences in the concentrations and ratios of amino acids became less as feeding progressed with age. Plasma total protein, albumin, prealbumin, calcium, magnesium, and alkaline phosphatase were not different between groups. CONCLUSION: Healthy infants fed an experimental partially hydrolyzed rice protein-based formula had normal growth, tolerance, and plasma biochemistry comparable to those of infants fed a standard intact milk protein-based formula, despite some differences in amino acid profiles.
John B Lasekan; Winston W K Koo; Jocelyn Walters; Michael Neylan; Steven Luebbers
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  25     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-9     Citation Subset:  IM    
Ross Products Division, Abbott Laboratories, Columbus, Ohio, USA.
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MeSH Terms
Amino Acids / administration & dosage,  blood*
Analysis of Variance
Blood Chemical Analysis
Body Height
Body Weight
Head / anatomy & histology
Infant Formula* / administration & dosage,  chemistry
Infant Nutritional Physiological Phenomena
Infant, Newborn / blood*,  growth & development*
Lysine / administration & dosage,  blood
Oryza sativa*
Prospective Studies
Threonine / administration & dosage,  blood
Grant Support
Reg. No./Substance:
0/Amino Acids; 56-87-1/Lysine; 72-19-5/Threonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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