| Growth and shrinkage of Pluronic micelles by uptake and release of flurbiprofen: variation of pH. | |
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MedLine Citation:
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PMID: 22471962 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The micellization of Pluronic triblock copolymers (P103, P123, and L43) in the presence of flurbiprofen at different pH was studied by small-angle neutron scattering (SANS), pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFGSE - NMR) and surface tension measurements. Addition of flurbiprofen to the Pluronic at low pH leads to an increase in the fraction of micellisation, aggregation number, and the core radius of the micelles. However, changing the pH to above the pKa of flurbiprofen in an ethanol/water mixture (~ 6.5) reduces the fraction of micellization and results in a weaker interaction between the drug and micelles due to the increased drug solubility in aqueous solution.. |
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Authors:
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Shirin Alexander; Wiebe Matthijs de Vos; Thomas Castle; Terence Cosgrove; Stuart W Prescott |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-3 |
Journal Detail:
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Title: Langmuir : the ACS journal of surfaces and colloids Volume: - ISSN: 1520-5827 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882736 Medline TA: Langmuir Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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